Association between air pollution exposure and mental health service use among individuals with first presentations of psychotic and mood disorders: retrospective cohort study

被引:60
作者
Newbury, Joanne B. [1 ,2 ,3 ]
Stewart, Robert [4 ,5 ]
Fisher, Helen L. [3 ,6 ]
Beevers, Sean [7 ,8 ]
Dajnak, David [7 ,8 ]
Broadbent, Matthew [4 ,9 ]
Pritchard, Megan [4 ,9 ]
Shiode, Narushige [10 ]
Heslin, Margaret [11 ]
Hammoud, Ryan [12 ]
Hotopf, Matthew [4 ,5 ]
Hatch, Stephani L. [4 ,6 ]
Mudway, Ian S. [7 ,8 ,13 ]
Bakolis, Ioannis [14 ,15 ]
机构
[1] Univ Bristol, Ctr Acad Mental Hlth, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
[2] Univ Bristol, MRC Integrat Jicerniol Unit, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
[3] Kings Coll Landon, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England
[4] Kings Coll London, Psychol Med, Inst Psychiat Psychol & Neurosci, London, England
[5] South London & Maudsley NHS Fdn Trust, London, England
[6] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England
[7] Imperial Coll London, Fac Med, Sch Publ Hlth, Environm Res Grp, London, England
[8] Imperial Coll London, Fac Med, MRC Ctr Environm & Hlth, Sch Publ Hlth, London, England
[9] South London & Maudsley NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
[10] Kings Coll London, Dept Geog, London, England
[11] Kings Coll London, Inst Psychiat Psychol & Neurosci, Kings Hlth Econ, London, England
[12] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Div Acad Psychiat, London, England
[13] Imperial Coll London, Fac Med, NIHR Hlth Protect Res Unit Environm Exposures & H, Sch Publ Hlth, London, England
[14] Kings Coll London, Ctr Implementat Sci, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England
[15] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London, England
基金
英国医学研究理事会; 英国经济与社会研究理事会; 英国惠康基金;
关键词
Air pollution; psychotic disorders; mood disorders; cohort study; illness severity and relapse; LIFETIME PREVALENCE; RISK; DEPRESSION; COST;
D O I
10.1192/bjp.2021.119
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Growing evidence suggests that air pollution exposure may adversely affect the brain and increase risk for psychiatric disorders such as schizophrenia and depression. However, little is known about the potential role of air pollution in severity and relapse following illness onset. Aims To examine the longitudinal association between residential air pollution exposure and mental health service use (an indicator of illness severity and relapse) among individuals with first presentations of psychotic and mood disorders. Method We identified individuals aged >= 15 years who had first contact with the South London and Maudsley NHS Foundation Trust for psychotic and mood disorders in 2008-2012 (n = 13 887). High-resolution (20 x 20 m) estimates of nitrogen dioxide (NO2), nitrogen oxides (NOx) and particulate matter (PM2.5 and PM10) levels in ambient air were linked to residential addresses. In-patient days and community mental health service (CMHS) events were recorded over 1-year and 7-year follow-up periods. Results Following covariate adjustment, interquartile range increases in NO2, NOx and PM2.5 were associated with 18% (95% CI 5-34%), 18% (95% CI 5-34%) and 11% (95% CI 3-19%) increased risk for in-patient days after 1 year. Similarly, interquartile range increases in NO2, NOx, PM2.5 and PM10 were associated with 32% (95% CI 25-38%), 31% (95% CI 24-37%), 7% (95% CI 4-11%) and 9% (95% CI 5-14%) increased risk for CMHS events after 1 year. Associations persisted after 7 years. Conclusions Residential air pollution exposure is associated with increased mental health service use among people recently diagnosed with psychotic and mood disorders. Assuming causality, interventions to reduce air pollution exposure could improve mental health prognoses and reduce healthcare costs.
引用
收藏
页码:678 / 685
页数:8
相关论文
共 25 条
[1]  
[Anonymous], 2015, EC COST HLTH IMPACT
[2]   Environmental pollution and risk of psychotic disorders: A review of the science to date [J].
Attademo, Luigi ;
Bernardini, Francesco ;
Garinella, Raffaele ;
Compton, Michael T. .
SCHIZOPHRENIA RESEARCH, 2017, 181 :55-59
[3]   Ambient concentrations of NO2 and hospital admissions for schizophrenia [J].
Bai, Lijun ;
Zhang, Xulai ;
Zhang, Yanwu ;
Cheng, Qiang ;
Duan, Jun ;
Gao, Jiaojiao ;
Xu, Zihan ;
Zhang, Heng ;
Wang, Shusi ;
Su, Hong .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2019, 76 (02) :125-131
[4]  
BAKOLIS I, 2020, SOC PSYCH PSYCH EPID, DOI DOI 10.1007/S00127-020-1966-X
[5]   Air pollution dispersion models for human exposure predictions in London [J].
Beevers, Sean D. ;
Kitwiroon, Nutthida ;
Williams, Martin L. ;
Kelly, Frank J. ;
Anderson, H. Ross ;
Carslaw, David C. .
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 2013, 23 (06) :647-653
[6]   Air pollution: mechanisms of neuroinflammation and CNS disease [J].
Block, Michelle L. ;
Calderon-Garciduenas, Lilian .
TRENDS IN NEUROSCIENCES, 2009, 32 (09) :506-516
[7]   Air Pollution (Particulate Matter) Exposure and Associations with Depression, Anxiety, Bipolar, Psychosis and Suicide Risk: A Systematic Review and Meta-Analysis [J].
Braithwaite, Isobel ;
Zhang, Shuo ;
Kirkbride, James B. ;
Osborn, David P. J. ;
Hayes, Joseph F. .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (12)
[8]   GATE, a general architecture for text engineering [J].
Cunningham, H .
COMPUTERS AND THE HUMANITIES, 2002, 36 (02) :223-254
[9]   Ethnic differences in risk of compulsory psychiatric admission among representative cases of psychosis in London [J].
Davies, S ;
Thornicroft, G ;
Leese, M ;
Higgingbotham, A ;
Phelan, M .
BRITISH MEDICAL JOURNAL, 1996, 312 (7030) :533-537
[10]   Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis (Publication with Expression of Concern) [J].
Fraguas, David ;
Diaz-Caneja, Covadonga M. ;
Ayora, Miriam ;
Hernandez-Alvarez, Fabian ;
Rodriguez-Quiroga, Alberto ;
Recio, Sandra ;
Leza, Juan C. ;
Arango, Celso .
SCHIZOPHRENIA BULLETIN, 2019, 45 (04) :742-751