Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment

被引：52
作者：
Lajoie, Annie C. [1 ]
Lafontaine, Anne-Louise [2 ]
Kimoff, R. John [1 ,3 ,4 ]
Kaminska, Marta [1 ,3 ,4 ]
机构：
[1] McGill Univ, Hlth Ctr, Res Inst, Resp Epidemiol & Clin Res Unit, Montreal, PQ H4A 3S5, Canada
[2] McGill Univ, Hlth Ctr, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
[3] McGill Univ, Hlth Ctr, Resp Div, Montreal, PQ H4A 3J1, Canada
[4] McGill Univ, Hlth Ctr, Sleep Lab, Montreal, PQ H4A 3J1, Canada
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 02期
关键词：
obstructive sleep apnea; neurodegenerative diseases; Parkinson's disease; Alzheimer's disease; POSITIVE AIRWAY PRESSURE; MILD COGNITIVE IMPAIRMENT; WAKE-ACTIVE NEURONS; PARKINSONS-DISEASE; BEHAVIOR DISORDER; INTERMITTENT HYPOXIA; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; AUTONOMIC DYSFUNCTION; LOCUS-COERULEUS;
D O I：
10.3390/jcm9020297
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway obstruction during sleep resulting in intermittent hypoxemia and sleep fragmentation. Research has recently increasingly focused on the impact of OSA on the brain's structure and function, in particular as this relates to neurodegenerative diseases. This article reviews the links between OSA and neurodegenerative disease, focusing on Parkinson's disease, including proposed pathogenic mechanisms and current knowledge on the effects of treatment.
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页数：24
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