Arginine methylation in the epithelial-to-mesenchymal transition

被引：7

作者：

Qin, Jian ^{[1
]}

Xu, Jian ^{[2
,3
,4
]}

机构：

[1] Wuhan Univ, Cent Lab, Renmin Hosp, Wuhan, Peoples R China

[2] Univ Southern Calif, Ctr Craniofacial Mol Biol, Herman Ostrow Sch Dent, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Biochem & Mol Med, Los Angeles, CA 90007 USA

[4] Univ Southern Calif, Norris Canc Ctr, Keck Sch Med, Los Angeles, CA 90007 USA

来源：

FEBS JOURNAL | 2022年 / 289卷 / 23期

关键词：

differentiation; epithelial-mesenchymal transition; methyltransferase; PRMT; protein arginine methylation; CANCER-CELL INVASION; TRANSCRIPTION FACTOR SNAIL; E-CADHERIN; HISTONE H3; EXPRESSION; PROMOTES; ISOFORM; EMT; PHOSPHORYLATION; LOCALIZATION;

D O I：

10.1111/febs.16152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epithelial cells acquire mesenchymal characteristics during embryonic development, wound healing, fibrosis, and in cancer in a processed termed epithelial-to-mesenchymal transition (EMT). Regulatory networks of EMT are controlled by post-transcriptional, translational, and post-translational mechanisms, in which arginine methylation is critically involved. Here, we review arginine methylation-dependent mechanisms that regulate EMT in the aspects of signaling, transcriptional, and splicing regulation.

引用

页码：7292 / 7303

页数：12

共 105 条

[1] Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing [J].

Adamopoulos, Panagiotis G. ;

Mavrogiannis, Adamantios V. ;

Kontos, Christos K. ;

Scorilas, Andreas .

GENE, 2019, 699 :135-144

[2] Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation [J].

Albrecht, Lauren V. ;

Bui, Maggie H. ;

De Robertis, Edward M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (08) :2987-2995

[3] Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking [J].

Albrecht, Lauren, V ;

Ploper, Diego ;

Tejeda-Munoz, Nydia ;

De Robertis, Edward M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (23) :E5317-E5325

[4] Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAF [J].

Andreu-Perez, Pedro ;

Esteve-Puig, Rosaura ;

de Torre-Minguela, Carlos ;

Lopez-Fauqued, Marta ;

Josep Bech-Serra, Joan ;

Tenbaum, Stephan ;

Garcia-Trevijano, Elena R. ;

Canals, Francesc ;

Merlino, Glenn ;

Avila, Matias A. ;

Recio, Juan A. .

SCIENCE SIGNALING, 2011, 4 (190)

[5] EMT: 2016 [J].

Angela Nieto, M. ;

Huang, Ruby Yun-Ju ;

Jackson, Rebecca A. ;

Thiery, Jean Paul .

CELL, 2016, 166 (01) :21-45

[6] PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer [J].

Avasarala, Sreedevi ;

Van Scoyk, Michelle ;

Rathinam, Manoj Kumar Karuppusamy ;

Zerayesus, Sereke ;

Zhao, Xiangmin ;

Zhang, Wei ;

Pergande, Melissa R. ;

Borgia, Jeffrey A. ;

DeGregori, James ;

Port, J. David ;

Winn, Robert A. ;

Bikkavilli, Rama Kamesh .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (21) :13479-13489

[7] Identification of the PRMT1v1 and PRMT1v2 specific interactomes by quantitative mass spectrometry in breast cancer cells [J].

Baldwin, R. Mitchell ;

Bejide, Margaret ;

Trinkle-Mulcahy, Laura ;

Cote, Jocelyn .

PROTEOMICS, 2015, 15 (13) :2187-2197

[8] Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression [J].

Baldwin, R. Mitchell ;

Haghandish, Nasim ;

Daneshmand, Manijeh ;

Amin, Shahrier ;

Paris, Genevieve ;

Falls, Theresa J. ;

Bell, John C. ;

Islam, Shahidul ;

Cote, Jocelyn .

ONCOTARGET, 2015, 6 (05) :3013-3032

[9] Alternatively spliced protein arginine methyltransferase 1 isoform PRMT1v2 promotes the survival and invasiveness of breast cancer cells [J].

Baldwin, R. Mitchell ;

Morettin, Alan ;

Paris, Genevieve ;

Goulet, Isabelle ;

Cote, Jocelyn .

CELL CYCLE, 2012, 11 (24) :4597-4612

[10] The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells [J].

Batlle, E ;

Sancho, E ;

Franci, C ;

Domínguez, D ;

Monfar, M ;

Baulida, J ;

de Herreros, AG .

NATURE CELL BIOLOGY, 2000, 2 (02) :84-89

← 1 2 3 4 5 6 7 8 9 10 →