Nucleic Acid-based Immuno-prophylaxis and -therapies against Tropical Diseases

被引：1
|
作者：
Ishii, Ken J. [1 ,2 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Div Vaccine Sci, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan
[2] Natl Inst Biomed Innovat Hlth & Nutr, Ctr Vaccine & Adjuvant Res, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2022年 / 142卷 / 07期
关键词：
CpG oligodeoxynucleotide (ODN); D35; neglected tropical disease; cutaneous leishmaniasis; drug development;
D O I：
10.1248/yakushi.21-00210-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The number of clinical trials investigating the use of nucleic acid drugs, including DNA/RNA-based vaccines, immunostimulatory/modulatory DNA/RNA and cyclic dinucleotides, for immuno-prophylaxis and -therapy has been increasing exponentially in recent years. These new drugs have revealed their therapeutic potential not only as vaccines or adjuvant therapies, but also as monotherapies for use in immuno-therapy of cancer and allergic disease. I will present an overview of their current R&D taking place in this field, then describe our recent progress, particularly regarding CpG oligodeoxynucleotides (ODNs), such as K3, K3-SPG, and D35 as either vaccine adjuvants or mono-immunotherapeutic agents for tropical diseases including malaria and leishmaniasis.
引用
收藏
页码：709 / 713
页数：5
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