Carbon-carbon bond-forming solid-phase reactions. Part II

被引:233
作者
Sammelson, RE [1 ]
Kurth, MJ [1 ]
机构
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
关键词
D O I
10.1021/cr000086e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The solid-phase organic synthesis (SPOS) methods were used to study the carbon-carbon bond-forming reactions for the generation of combinatorial libraries of compounds. The carbon-carbon bond-forming reactions were used to show the utility of the novel linkers for the SPOS. A large number of new linkers with different cleavage protocols were used for SPOS. Palladium-catalyzed coupling reactions were employed for creating carbon-carbon bonds in polymer-supported reactions.
引用
收藏
页码:137 / 202
页数:66
相关论文
共 267 条
[1]   A reinvestigation of the preparation, properties, and applications of aminomethyl and 4-methylbenzhydrylamine polystyrene resins [J].
Adams, JH ;
Cook, RM ;
Hudson, D ;
Jammalamadaka, V ;
Lyttle, MH ;
Songster, MF .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (11) :3706-3716
[2]   A recyclable 'boomerang' polymer-supported ruthenium catalyst for olefin metathesis [J].
Ahmed, M ;
Barrett, AGM ;
Braddock, DC ;
Cramp, SM ;
Procopiou, PA .
TETRAHEDRON LETTERS, 1999, 40 (49) :8657-8662
[3]   Solid-phase oligosaccharide synthesis: Preparation of complex structures using a novel linker and different glycosylating agents [J].
Andrade, RB ;
Plante, OJ ;
Melean, LG ;
Seeberger, PH .
ORGANIC LETTERS, 1999, 1 (11) :1811-1814
[4]  
[Anonymous], 1890, BER DTSCH CHEM GES, DOI DOI 10.1002/CBER.189002301243
[5]   Chameleon catches in combinatorial chemistry:: Tebbe olefination of polymer supported esters and the synthesis of amines, cyclohexanones, enones, methyl ketones and thiazoles [J].
Ball, CP ;
Barrett, AGM ;
Commerçon, A ;
Compère, D ;
Kuhn, C ;
Roberts, RS ;
Smith, ML ;
Venier, O .
CHEMICAL COMMUNICATIONS, 1998, (18) :2019-2020
[6]   Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives. [J].
Barco, A ;
Benetti, S ;
De Risi, C ;
Marchetti, P ;
Pollini, GP ;
Zanirato, V .
TETRAHEDRON LETTERS, 1998, 39 (41) :7591-7594
[7]   ROMP-spheres: A novel high-loading polymer support using cross metathesis between vinyl polystyrene and norbornene derivatives [J].
Barrett, AGM ;
Cramp, SM ;
Roberts, RS .
ORGANIC LETTERS, 1999, 1 (07) :1083-1086
[8]   The Baylis-Hillman reaction: A novel carbon-carbon bond forming reaction [J].
Basavaiah, D ;
Rao, PD ;
Hyma, RS .
TETRAHEDRON, 1996, 52 (24) :8001-8062
[9]   Arylsulfonate esters in solid phase organic synthesis. II. Compatibility with commonly-used reaction conditions [J].
Baxter, EW ;
Rueter, JK ;
Nortey, SO ;
Reitz, AB .
TETRAHEDRON LETTERS, 1998, 39 (09) :979-982
[10]  
Baylis A. B, 1972, German Patent, Patent No. 2155113