Adipose-Derived Stem Cells for Wound Healing Applications

被引：127

作者：

Cherubino, Mario ^{[1
]}

Rubin, J. Peter ^{[1
,2
,3
]}

Miljkovic, Natasa ^{[1
]}

Kelmendi-Doko, Arta ^{[1
]}

Marra, Kacey G. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Surg, Div Plast Surg, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, McGowan Inst Regenerat Med, Div Plast Surg, Pittsburgh, PA 15261 USA

来源：

ANNALS OF PLASTIC SURGERY | 2011年 / 66卷 / 02期

关键词：

adipose-derived stem cells; soft tissue repair; wound healing; DIABETIC FOOT ULCERS; IMPROVE POSTNATAL NEOVASCULARIZATION; ACELLULAR DERMAL MATRIX; PLATELET-RICH PLASMA; STROMAL CELLS; GROWTH-FACTOR; IN-VITRO; PROGENITOR CELLS; CUTANEOUS WOUNDS; SKIN FLAPS;

D O I：

10.1097/SAP.0b013e3181e6d06c

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Nonhealing wounds remain a significant challenge for plastic surgeons. More than 600,000 people suffer from venous ulcers and 1.5 to 3 million people are being treated for pressure sores every year in the United States. The use of tissue engineering techniques such as stem-cell therapy and gene therapy to improve wound healing is a promising strategy. Adipose tissue represents a source of cells that may be able to enhance wound healing. Adipose-derived stem cells (ASCs) are adult stem cells that are easily harvested and of great interest for plastic surgeons. Specifically, ASCs secrete angiogenic growth factors that can induce tissue regeneration. This review describes innovative research strategies using ASCs therapies for treatment of chronic, nonhealing wounds.

引用

页码：210 / 215

页数：6

共 125 条

[91] Wound infection - A failure of wound healing caused by an imbalance of bacteria
Robson, MC
[J]. SURGICAL CLINICS OF NORTH AMERICA, 1997, 77 (03) : 637 - &
[92] Rogers Alan A., 1995, Wound Repair and Regeneration, V3, P273, DOI 10.1046/j.1524-475X.1995.30307.x
[93] ROSENBERG DS, 2004, WOUND REPAIR REGEN, V12, pA12
[94] Loss of vascular endothelial growth factor A activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation
Rossiter, H
Barresi, C
Pammer, J
Rendl, M
Haigh, J
Wagner, EF
Tschachler, E
[J]. CANCER RESEARCH, 2004, 64 (10) : 3508 - 3516
[95] Collagenous microbeads as a scaffold for tissue engineering with adipose-derived stem cells
Rubin, J. Peter
Bennett, Jennifer M.
Doctor, John S.
Tebbets, Bradley M.
Marra, Kacey G.
[J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2007, 120 (02) : 414 - 424
[96] Regional anatomic and age effects on cell function of human adipose-derived stem cells
Schipper, Bret M.
Marra, Kacey G.
Zhang, Wei
Donnenberg, Albert D.
Rubin, J. Peter
[J]. ANNALS OF PLASTIC SURGERY, 2008, 60 (05) : 538 - 544
[97] Differential expression of proteins during healing of cutaneous wounds in experimental normal and chronic models
Shukla, A
Dubey, MP
Srivastava, R
Srivastava, BS
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 244 (02) : 434 - 439
[98] The social and economic burden of venous leg ulcers - Focus on the role of micronized purified flavonoid fraction adjuvant therapy
Simka, M
Majewski, E
[J]. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2003, 4 (08) : 573 - 581
[99] Improved survival of ischemic random skin flaps through the use of bone marrow nonhematopoietic stem cells and angiogenic growth factors
Simman, R
Craft, C
McKinney, B
[J]. ANNALS OF PLASTIC SURGERY, 2005, 54 (05) : 546 - 552
[100] Mechanisms of disease - Cutaneous wound healing
Singer, AJ
Clark, RAF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (10) : 738 - 746

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