Adipose-Derived Stem Cells for Wound Healing Applications

被引：127
作者：
Cherubino, Mario [1 ]
Rubin, J. Peter [1 ,2 ,3 ]
Miljkovic, Natasa [1 ]
Kelmendi-Doko, Arta [1 ]
Marra, Kacey G. [1 ,2 ,3 ]
机构：
[1] Univ Pittsburgh, Dept Surg, Div Plast Surg, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, McGowan Inst Regenerat Med, Div Plast Surg, Pittsburgh, PA 15261 USA
来源：
ANNALS OF PLASTIC SURGERY | 2011年 / 66卷 / 02期
关键词：
adipose-derived stem cells; soft tissue repair; wound healing; DIABETIC FOOT ULCERS; IMPROVE POSTNATAL NEOVASCULARIZATION; ACELLULAR DERMAL MATRIX; PLATELET-RICH PLASMA; STROMAL CELLS; GROWTH-FACTOR; IN-VITRO; PROGENITOR CELLS; CUTANEOUS WOUNDS; SKIN FLAPS;
D O I：
10.1097/SAP.0b013e3181e6d06c
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Nonhealing wounds remain a significant challenge for plastic surgeons. More than 600,000 people suffer from venous ulcers and 1.5 to 3 million people are being treated for pressure sores every year in the United States. The use of tissue engineering techniques such as stem-cell therapy and gene therapy to improve wound healing is a promising strategy. Adipose tissue represents a source of cells that may be able to enhance wound healing. Adipose-derived stem cells (ASCs) are adult stem cells that are easily harvested and of great interest for plastic surgeons. Specifically, ASCs secrete angiogenic growth factors that can induce tissue regeneration. This review describes innovative research strategies using ASCs therapies for treatment of chronic, nonhealing wounds.
引用
收藏
页码：210 / 215
页数：6
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