A general and practical preparation of alkylidene Meldrum's acids

被引：57

作者：

Dumas, Aaron M. ^{[1
]}

Seed, Adam ^{[1
]}

Zorzitto, Alexander K. ^{[1
]}

Fillion, Eric ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 40期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

D O I：

10.1016/j.tetlet.2007.08.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Although many methods have been reported for the Knoevenagel condensation of aldehydes and Meldrum's acid, most are not general or use unconventional reagents and conditions. We have found that alkylidene Meldrum's acids form readily in benzene solution under mild pyrrolidinium acetate catalysis, and that this reaction is general, highly functional group compatible, and can be scaled-up easily. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7072 / 7074

页数：3

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