Dendritic spines and long-term plasticity

被引：378
作者：
Segal, M [1 ]
机构：
[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
来源：
NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 04期
基金：
以色列科学基金会;
关键词：
D O I：
10.1038/nrn1649
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A recent flurry of time-lapse imaging studies of live neurons have tried to address the century-old question: what morphological changes in dendritic spines can be related to long-term memory? Changes that have been proposed to relate to memory include the formation of new spines, the enlargement of spine heads and the pruning of spines. These observations also relate to a more general question of how stable dendritic spines are. The objective of this review is to critically assess the new data and to propose much needed criteria that relate spines to memory, thereby allowing progress in understanding the morphological basis of memory.
引用
收藏
页码：277 / 284
页数：8
相关论文
共 83 条
[1]   Stability of dendritic spines and synaptic contacts is controlled by αN-catenin [J].
Abe, K ;
Chisaka, O ;
van Roy, F ;
Takeichi, M .
NATURE NEUROSCIENCE, 2004, 7 (04) :357-363
[2]   Differences in the complexity of song tutoring cause differences in the amount learned and in dendritic spine density in a songbird telencephalic song control nucleus [J].
Airey, DC ;
Kroodsma, DE ;
DeVoogd, TJ .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2000, 73 (03) :274-281
[3]  
Bernstein BW, 2003, J NEUROSCI, V23, P1
[4]   Blockade of N-methyl-D-aspartate receptor activation suppresses learning-induced synaptic elimination [J].
Bock, J ;
Braun, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2485-2490
[5]   The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus [J].
Boda, B ;
Alberi, S ;
Nikonenko, I ;
Node-Langlois, R ;
Jourdain, P ;
Moosmayer, M ;
Parisi-Jourdain, L ;
Muller, D .
JOURNAL OF NEUROSCIENCE, 2004, 24 (48) :10816-10825
[6]  
Cajal S. R., 1995, HIST NEUROSCIENCE
[7]   PLASTICITY IN THE CENTRAL NERVOUS-SYSTEM - DO SYNAPSES DIVIDE [J].
CARLIN, RK ;
SIEKEVITZ, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (11) :3517-3521
[8]  
Dailey ME, 1996, J NEUROSCI, V16, P2983
[9]   Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity [J].
Deller, T ;
Korte, M ;
Chabanis, S ;
Drakew, A ;
Schwegler, H ;
Stefani, GG ;
Zuniga, A ;
Schwarz, K ;
Bonhoeffer, T ;
Zeller, R ;
Frotscher, M ;
Mundel, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10494-10499
[10]   CHANGES IN THE POSTSYNAPTIC DENSITY WITH LONG-TERM POTENTIATION IN THE DENTATE GYRUS [J].
DESMOND, NL ;
LEVY, WB .
JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 253 (04) :476-482
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