Endostatin promotes the anabolic program of rabbit chondrocyte

被引：16

作者：

Feng, Y ^{[1
]}

Wu, YP ^{[1
]}

Zhu, XD ^{[1
]}

Zhang, YH ^{[1
]}

Ma, QJ ^{[1
]}

机构：

[1] Beijing Inst Biotechnol, Dept Mol Genet, Beijing 100850, Peoples R China

来源：

CELL RESEARCH | 2005年 / 15卷 / 03期

关键词：

endostatin; angiogenesis; chondrocyte; matrix metalloproteinase;

D O I：

10.1038/sj.cr.7290287

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism.

引用

页码：201 / 206

页数：6

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