Electrogenerated chemiluminescence aptamer-based biosensor for the determination of cocaine
被引:132
作者:
Li, Yan
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机构:
Shaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R ChinaShaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China
Li, Yan
[1
]
Qi, Honglan
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机构:
Shaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R ChinaShaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China
Qi, Honglan
[1
]
Peng, Yage
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机构:
Shaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R ChinaShaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China
Peng, Yage
[1
]
Yang, Jia
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机构:
Shaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R ChinaShaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China
Yang, Jia
[1
]
Zhang, Chengxiao
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机构:
Shaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R ChinaShaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China
Zhang, Chengxiao
[1
]
机构:
[1] Shaanxi Normal Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China
biosensor;
aptamer;
electrogenerated chemiluminescence;
cocaine;
tris (2,2'-bipyridyl) ruthenium derivatives;
D O I:
10.1016/j.elecom.2007.07.038
中图分类号:
O646 [电化学、电解、磁化学];
学科分类号:
081704 ;
摘要:
A novel electrogenerated chemiluminescence aptamer-based (ECL-AB) biosensor for the determination of a small molecule drug is designed employing cocaine-binding aptamer as molecular recognition element for cocaine as a model analyte and ruthenium complex served as an ECL label. A 5'-terminal cocaine-binding aptamer with the ECL label at 3'-terminal of the aptamer was utilized as an ECL probe. The ECL-AB biosensors were fabricated by immobilizing the ECL probe onto a gold electrode surface via thiol-Au interactions. An enhanced ECL signal is generated upon recognition of the target cocaine, attributed to a change in the conformation of the ECL probe from random coil-like configuration on the probe-modified film to three-way junction structure, in close proximity to the sensor interface. The integrated ECL intensity versus the concentration of cocaine was linear in the range from 5.0 x 10(-9) to 3.0 x 10(-7) M. The detection limit was 1.0 x 10(-9) M. This work demonstrates that the combination of a highly binding aptamer to analyte with a highly sensitive ECL technique to design ECL-AB biosensor is a great promising approach for the determination of small molecule drugs. (C) 2007 Elsevier B.V. All rights reserved.
机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Hamula, Camille L. A.
Guthrie, Jeffrey W.
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机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Guthrie, Jeffrey W.
Zhang, Hongquan
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机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Zhang, Hongquan
Li, Xing-Fang
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机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Li, Xing-Fang
Le, X. Chris
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机构:
Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, CanadaUniv Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
机构:Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
Kawde, AN
Rodriguez, MC
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机构:Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
Rodriguez, MC
Lee, TMH
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机构:Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
Lee, TMH
Wang, J
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h-index: 0
机构:
Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USAArizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Hamula, Camille L. A.
Guthrie, Jeffrey W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Guthrie, Jeffrey W.
Zhang, Hongquan
论文数: 0引用数: 0
h-index: 0
机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Zhang, Hongquan
Li, Xing-Fang
论文数: 0引用数: 0
h-index: 0
机构:Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
Li, Xing-Fang
Le, X. Chris
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, CanadaUniv Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
机构:Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
Kawde, AN
Rodriguez, MC
论文数: 0引用数: 0
h-index: 0
机构:Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
Rodriguez, MC
Lee, TMH
论文数: 0引用数: 0
h-index: 0
机构:Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA
Lee, TMH
Wang, J
论文数: 0引用数: 0
h-index: 0
机构:
Arizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USAArizona State Univ, Biodesign Inst, Dept Chem & Mat Engn, Tempe, AZ 85287 USA