New and efficient synthesis of dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates

被引：70
作者：
Shaabani, A
Yavari, I
Teimouri, MB
Bazgir, A
Bijanzadeh, HR
机构：
[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran
来源：
TETRAHEDRON | 2001年 / 57卷 / 07期
关键词：
dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates; Meldrum's acid; 4-nitrobenzaldehyde;
D O I：
10.1016/S0040-4020(00)01122-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The condensation product of Meldrum's acid and 4-nitrobenzaldehyde reacts smoothly with alkyl isocyanides in the presence of alcohols to produce dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates in excellent yield. This reaction provides a useful synthetic route to highly functionalized amidodiesters. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1375 / 1378
页数：4
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