New and efficient synthesis of dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates

被引：70

作者：

Shaabani, A

Yavari, I

Teimouri, MB

Bazgir, A

Bijanzadeh, HR

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON | 2001年 / 57卷 / 07期

关键词：

dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates; Meldrum's acid; 4-nitrobenzaldehyde;

D O I：

10.1016/S0040-4020(00)01122-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The condensation product of Meldrum's acid and 4-nitrobenzaldehyde reacts smoothly with alkyl isocyanides in the presence of alcohols to produce dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates in excellent yield. This reaction provides a useful synthetic route to highly functionalized amidodiesters. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1375 / 1378

页数：4

共 10 条

[1] A SPECTACULAR EXAMPLE OF THE IMPORTANCE OF ROTATIONAL BARRIERS - THE IONIZATION OF MELDRUMS ACID [J].