Molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa carrying metallo-β-lactamase genes in Taiwan

被引：24
作者：
Huang, Yu-Tsung
Chang, Shan-Chwen
Lauderdale, Tsai-Ling
Yang, Almira J.
Wang, Jann-Tay [1 ]
机构：
[1] Natl Taiwan Univ Hosp, Natl Taiwan Univ Coll Med, Dept Internal Med, Taipei 100, Taiwan
[2] Natl Hlth Res Inst, Div Clin Res, Zhunan 350, Taiwan
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2007年 / 59卷 / 02期
关键词：
carbapenem resistance; Pseudomonas aeruginosa; metallo-beta-lactamase; colistin;
D O I：
10.1016/j.diagmicrobio.2007.01.009
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Seventy-two isolates of carbapenem-resistant Pseudomonas aeruginosa (CRPA) collected through the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program in 2000 and 2002 were studied for carriage of metallo-beta-laetamase (MBL), integrase genes, and integrons. Epidemiologic relatedness was determined using pulsed-field gel electrophoresis. The prevalence of the MBL genes among CRPA was 36.0% (9 of 25) in TSAR II and 17.0% (8/47) in TSAR III, with prevalence in surveyed hospitals being 19.1% (4/21, TSAR II) and 23.1% (6 of 26, TSAR III). The bla(VIM-3) was detected in 15 of the 17 MBL-positive isolates; the remainder possessed bla(VIM-2). The bla(IMP) was not evident. Class 1 integron was detected in all MBL-positive isolates; amplicon DNA sequences containing the bla(VIM-3) regions were all identical. All MBL-positive isolates remained susceptible to colistin. Molecular typing revealed a predominant strain that comprised 14 of the isolates among the various surveyed hospitals. (C) 2007 Elsevier Inc. All rights reserved.
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收藏
页码：211 / 216
页数：6
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