MicroRNAs and Ultraconserved Genes as Diagnostic Markers and Therapeutic Targets in Cancer and Cardiovascular Diseases

被引:43
|
作者
Edwards, Julianna K. [3 ]
Pasqualini, Renata [3 ]
Arap, Wadih [3 ]
Calin, George A. [1 ,2 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNAs, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, David H Koch Ctr, Houston, TX 77030 USA
关键词
MicroRNA; Ultraconserved Gene; Diagnosis; Therapy; TUMOR-SUPPRESSOR GENE; CARDIAC-HYPERTROPHY; EXPRESSION; HEART; LET-7; METASTASIS; SIGNATURE; GERMLINE; MIR-133; ANGIOGENESIS;
D O I
10.1007/s12265-010-9179-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
MicroRNAs (miRNAs), approximately 19-25 nucleotides in length, are posttranscriptional regulators of protein expression that target and inhibit translation of messenger (m) RNAs. Recent research on miRNAs has produced a plethora of new material on the role of miRNAs in disease. Deregulation or ablation of miRNA expression has led to major pathologies including heart disease and cancer. Signatures of differential miRNA expression have been uncovered for nearly every disease. Recent research has focused on exploitation of the selectivity of these signatures as markers of disease and for therapeutic applications. The significance of additional mechanisms of abnormal posttranscriptional regulation, such as ultraconserved genes (UCGs), has recently been recognized. This review focuses on the identification of aberrant posttranscriptional regulators (miRNAs and UCGs) in cancer and cardiovascular disease and addresses the applications of this work towards diagnosis and therapy.
引用
收藏
页码:271 / 279
页数:9
相关论文
共 50 条
  • [31] MicroRNAs and human diseases: diagnostic and therapeutic potential
    Maqbool, Raihana
    Ul Hussain, Mahboob
    CELL AND TISSUE RESEARCH, 2014, 358 (01) : 1 - 15
  • [32] MicroRNAs and human diseases: diagnostic and therapeutic potential
    Raihana Maqbool
    Mahboob Ul Hussain
    Cell and Tissue Research, 2014, 358 : 1 - 15
  • [33] The role of miR-155 in cardiovascular diseases: Potential diagnostic and therapeutic targets
    Zhang, Rui-Lin
    Wang, Wei-Ming
    Li, Ji-Qiang
    Li, Run-Wen
    Zhang, Jie
    Wu, Ya
    Liu, Yong
    INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION, 2025, 24
  • [34] ROCKs as therapeutic targets in cardiovascular diseases
    Rikitake, Yoshiyuki
    Liao, James K.
    EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2005, 3 (03) : 441 - 451
  • [35] Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
    Hadler-Olsen, Elin
    Winberg, Jan-Olof
    Uhlin-Hansen, Lars
    TUMOR BIOLOGY, 2013, 34 (04) : 2041 - 2051
  • [36] Screening of potential diagnostic markers and therapeutic targets against colorectal cancer
    Tian, XiaoQing
    Sun, DanFeng
    Zhao, ShuLiang
    Xiong, Hua
    Fang, JingYuan
    ONCOTARGETS AND THERAPY, 2015, 8 : 1691 - 1699
  • [37] MicroRNAs in Leukemias: Emerging Diagnostic Tools and Therapeutic Targets
    Mian, Yousaf A.
    Zeleznik-Le, Nancy J.
    CURRENT DRUG TARGETS, 2010, 11 (07) : 801 - 811
  • [38] MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma: potential therapeutic targets and diagnostic/prognostic markers and web based tools
    Shakiba, Elham
    Boroomand, Seti
    Kia, Sima Kheradmand
    Hedayati, Mehdi
    ONCOLOGY RESEARCH, 2024, 32 (06) : 1011 - 1019
  • [39] MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases
    Wang, Xiaolin
    He, Yong
    Mackowiak, Bryan
    Gao, Bin
    GUT, 2021, 70 (04) : 784 - 795
  • [40] MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
    Srinivasan, Sakthivel
    Selvan, Subramanian Tamil
    Archunan, Govindaraju
    Gulyas, Balazs
    Padmanabhan, Parasuraman
    THERANOSTICS, 2013, 3 (12): : 919 - 931