Synthesis and reactions of 2-hydroxy-5,5-dimethyl- and 2-hydroxy-5,5-pentamethylene-2-trifluoromethyltetrahydro-4-pyranones with N-nucleophiles

被引：6

作者：

Sosnovskikh, VY ^{[1
]}

Mel'nikov, MY ^{[1
]}

Zaitsev, AV ^{[1
]}

Bogdanov, EA ^{[1
]}

机构：

[1] AM Gorky Ural State Univ, Ekaterinburg 620083, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 1998年 / 47卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

condensation; beta-hydroxyketones; ethyl trifluoroacetate; tetrahydro-4-pyranones; aminoenones; CF3-containing pyrazoles and Delta(2)-isoxazolines;

D O I：

10.1007/BF02503492

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of 4-hydroxy-3,3-dimethyl- and 4-hydroxy-3,3-pentamethylenebutan-2-ones with ethyl trifluoroacetate in the presence of LiH in hexane afforded 2-hydroxy-5,5-dimethyl- and 2-hydroxy-5,5-pentamethylene-2-trifluoromethyltetrahydro-4-pyranones, whose behavior in reactions with N-nucleophiles is analogous to that of unsymmetrical polyfluorinated beta-diketones.

引用

页码：1170 / 1174

页数：5

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Sosnovskikh VY, 1998, ZH ORG KHIM+, V34, P203

[7]

Sosnovskikh VY, 1998, ZH ORG KHIM+, V34, P303

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