Hearing restoration and the stria vascularis: evidence for the role of the immune system in hearing restoration

被引：1

作者：

Samaha, Nadia L. ^{[1
]}

Almasri, Mohamad M. ^{[1
]}

Johns, J. Dixon ^{[2
]}

Hoa, Michael ^{[2
,3
,4
,5
]}

机构：

[1] Georgetown Univ, Sch Med, Washington, DC USA

[2] Georgetown Univ, MedStar Georgetown Univ Hosp, Dept Otolaryngol Head & Neck Surg, Sch Med, Washington, DC USA

[3] Natl Inst Deafness & Other Commun Disorders, Auditory Dev & Restorat Program, NIH, Bethesda, MD 20892 USA

[4] Natl Inst Deafness & Other Commun Disorders, Otolaryngol Surg Scientist Program, NIH, Porter Neurosci Res Ctr, 35 Convent Dr,Room 1F-226, Bethesda, MD 20892 USA

[5] Natl Inst Deafness & Other Commun Disorders, Auditory Dev & Restorat Program, NIH, Porter Neurosci Res Ctr, 35 Convent Dr,Room 1F-226, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY | 2021年 / 29卷 / 05期

关键词：

autoimmune hearing loss; autoinflammatory hearing loss; immune-mediated hearing loss; stria vascularis; INNER-EAR DISEASE; NECROSIS-FACTOR-ALPHA; ENDOLYMPHATIC HYDROPS; LUPUS-ERYTHEMATOSUS; AUTOIMMUNE; INTERLEUKIN-1-BETA; AUTOINFLAMMATION; PATHOGENESIS; RECOGNITION; CELLS;

D O I：

10.1097/MOO.0000000000000738

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purpose of review This article reviews the current literature regarding the pathogenesis of immune-mediated sensorineural hearing loss, utilizes previously published single-nucleus transcriptional profiles to characterize cytokine and cytokine receptor expression in the adult stria vascularis cell types to support immune system interaction with the stria vascularis and reviews the current literature on immunomodulatory agents currently being used for hearing-restoration treatment. Recent findings The literature review highlights recent studies that elucidate many cytokines and immune markers, which have been linked to various immune-mediated disease processes that have been observed with sensorineural hearing loss within the stria vascularis and highlights recent publications studying therapeutic targets for these pathways. This review highlights the current literature regarding the pathogenesis of immune-mediated hearing loss. The role of cochlear structures in human temporal bones from patients with immune-mediated sensorineural hearing loss are highlighted, and we review cytokine signalling pathways relevant to immune-mediated sensorineural hearing loss and localize genes encoding both cytokine and cytokine receptors involved in these pathways. Finally, we review immunomodulatory therapeutics in light of these findings and point to opportunities for the application of novel therapeutics by targeting these signalling pathways.

引用

页码：373 / 384

页数：12

共 94 条

[1]

Abad S, 2014, MOL VIS, V20, P956

[2] Cryopyrin-Associated Periodic Syndromes: Otolaryngologic and Audiologic Manifestations [J].