Clinical practice - Drug desensitization in children

被引：26

作者：

de Groot, Hans ^{[1
]}

Mulder, W. M. C. ^{[2
]}

机构：

[1] RdGG, Diaconessenhuis Voorburg, Dept Pediat Allergol, NL-2275 CX Voorburg, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Pharmacol & Pharmacotherapy, NL-1105 AZ Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2010年 / 169卷 / 11期

关键词：

Children; Drug allergy; Prevalence; Desensitization; Protocol; ORAL DESENSITIZATION; TRIMETHOPRIM-SULFAMETHOXAZOLE; HYPERSENSITIVITY; METHOTREXATE; CARBOPLATIN; DIAGNOSIS; VIRUS;

D O I：

10.1007/s00431-010-1236-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Immediate type allergic reactions to medication are potentially life threatening and can hamper drug therapy of several medical conditions. Exact incidence and prevalence data for these reactions in children are lacking. If no alternative drug treatment is available, a desensitization procedure may secure the continuation of necessary therapy. Desensitization is only appropriate in case of a strong suspicion of an IgE-mediated allergic reaction. It should be performed by trained clinicians (allergy specialists) in a hospital setting where treatment of a potential anaphylactic reaction can be done without any delay. In this article, literature describing desensitization procedures for several antibiotics, antineoplastic agents, and vaccines in children is reviewed. In general, desensitization schemes for children differ only in final dose from schemes for adults. Contradictory data were found regarding the protective effects of premedication with antihistamines and glucocorticoids.

引用

页码：1305 / 1309

页数：5

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