Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372

被引：32

作者：

Enomoto, Y ^{[1
]}

Shiomi, K ^{[1
]}

Hayashi, M ^{[1
]}

Masuma, R ^{[1
]}

Kawakubo, T ^{[1
]}

Tomosawa, K ^{[1
]}

Iwai, Y ^{[1
]}

Omura, S ^{[1
]}

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期

关键词：

D O I：

10.7164/antibiotics.49.50

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg-372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 mu M, respectively.

引用

页码：50 / 53

页数：4