Synthesis and biological activities of 2-(1-aryl-3-methyl-5-chloro1H-pyrazol-4-yl)-3-(1-aroylamino)-4-thiazolidinones

The reactions of 1-aryl-3-methyl-5-chloro-1H-4-pyrazolylformaldehydes (2) with aroylhydrazines and followed by the addition of mercaptoacetic acid, eleven new compounds 2-(1-aryl-3-methyl-5chloro-1H-pyrazol-4-yl)-3-(1-aroylamino)-4-thiazolidinones 3asimilar to3k have been synthesized. Their structures were characterized by elemental analysis, IR and H-1 NMR spectra, and one of them 3d by X-ray diffraction study. The preliminary bioassay tests showed that compound 3e possessed moderate fungicidal activity and 3e and 3k only exhibited certain herbicidal activity.