99mTc Labelling Strategies for the Development of Potential Nitroimidazolic Hypoxia Imaging Agents

被引：12

作者：

Giglio, Javier ^{[1
]}

Rey, Ana ^{[1
]}

机构：

[1] Univ Republica, Fac Quim, Area Radioquim, Gen Flores 2124, Montevideo 11800, Uruguay

来源：

INORGANICS | 2019年 / 7卷 / 11期

关键词：

technetium-99m; hypoxia; nitroimidazoles; labelling strategies; IN-VITRO EVALUATION; BIOLOGICAL EVALUATION; TUMOR HYPOXIA; REDUCTION POTENTIALS; COMPLEXES; TECHNETIUM; LIGAND; RADIOPHARMACEUTICALS; MARKER; TC-99M-RADIOPHARMACEUTICALS;

D O I：

10.3390/inorganics7110128

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Technetium-99m has a rich coordination chemistry that offers many possibilities in terms of oxidation states and donor atom sets. Modifications in the structure of the technetium complexes could be very useful for fine tuning the physicochemical and biological properties of potential Tc-99m radiopharmaceuticals. However, systematic study of the influence of the labelling strategy on the "in vitro" and "in vivo" behaviour is necessary for a rational design of radiopharmaceuticals. Herein we present a review of the influence of the Tc complexes' molecular structure on the biodistribution and the interaction with the biological target of potential nitroimidazolic hypoxia imaging radiopharmaceuticals presented in the literature from 2010 to the present. Comparison with the gold standard [F-18]Fluoromisonidazole (FMISO) is also presented.

引用

页数：16

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