Multifunctional sequence-defined macromolecules for chemical data storage

被引：141

作者：

Martens, Steven ^{[1
]}

Landuyt, Annelies ^{[1
]}

Espeel, Pieter ^{[1
]}

Devreese, Bart ^{[2
]}

Dawyndt, Peter ^{[3
]}

Du Prez, Filip ^{[1
]}

机构：

[1] Univ Ghent, Ctr Macromol Chem CMaC, Dept Organ & Macromol Chem, Polymer Chem Res Grp, Krijgslaan 281 S4bis, B-9000 Ghent, Belgium

[2] Univ Ghent, Dept Biochem & Microbiol, Lab Prot Biochem & Biomol Engn, KL Ledeganckstr 35, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Appl Math, Comp Sci & Stat, Krijgslaan 281 S9, B-9000 Ghent, Belgium

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

PHOSPHORAMIDITE CHEMISTRY; INFORMATION-STORAGE; PHASE SYNTHESIS; POLYMERS; DNA; OLIGOMERS; GENERATION; MS/MS; IDENTIFICATION; COPOLYMERS;

D O I：

10.1038/s41467-018-06926-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sequence-defined macromolecules consist of a defined chain length (single mass), end-groups, composition and topology and prove promising in application fields such as anti-counterfeiting, biological mimicking and data storage. Here we show the potential use of multifunctional sequence-defined macromolecules as a storage medium. As a proof-of-principle, we describe how short text fragments (human-readable data) and QR codes (machine-readable data) are encoded as a collection of oligomers and how the original data can be reconstructed. The amide-urethane containing oligomers are generated using an automated protecting-group free, two-step iterative protocol based on thiolactone chemistry. Tandem mass spectrometry techniques have been explored to provide detailed analysis of the oligomer sequences. We have developed the generic software tools Chemcoder for encoding/decoding binary data as a collection of multifunctional macromolecules and Chemreader for reconstructing oligomer sequences from mass spectra to automate the process of chemical writing and reading.

引用

页数：8

共 55 条

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