Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women

被引:27
作者
Lee, A. H. [1 ]
Tan, L. B. [1 ]
Hiramatsu, N. [2 ]
Ishisaka, A. [2 ]
Alfonso, H. [1 ]
Tanaka, A. [3 ]
Uemura, N. [2 ]
Fujiwara, Y. [2 ]
Takechi, R. [1 ,3 ,4 ]
机构
[1] Curtin Univ, Fac Hlth Sci, Sch Publ Hlth, GPO Box U1987, Perth, WA 6845, Australia
[2] Univ Hyogo, Sch Human Sci & Environm, Himeji, Hyogo 6712201, Japan
[3] Kagawa Nutr Univ, Nutr Clin, Tokyo, Japan
[4] Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA 6845, Australia
来源
NUTRITION & DIABETES | 2016年 / 6卷
基金
英国医学研究理事会;
关键词
CHLOROGENIC ACID; GREEN TEA; GLUCOSE-TOLERANCE; CONSUMPTION; RELEASE; SAMPLES; HUMANS; MICE;
D O I
10.1038/nutd.2016.19
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This antidiabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and diabetic risks has never been investigated in the literature. In this study, fasting plasma samples were collected from 57 generally healthy females aged 38-73 (mean 52, s.d. 8) years recruited in Himeji, Japan. The concentrations of plasma coffee polyphenols were determined by liquid chromatography coupled with mass tandem spectrometer. Diabetes biomarkers in the plasma/serum samples were analysed by a commercial diagnostic laboratory. Statistical associations were assessed using Spearman's correlation coefficients. The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Our preliminary data support previous findings that coffee polyphenols have antidiabetic effects but further replications with large samples of both genders are recommended.
引用
收藏
页码:e212 / e212
页数:3
相关论文
共 15 条
  • [1] Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia
    Bassoli, Bruna Kempfer
    Cassolla, Priscila
    Borba-Murad, Glaucia Regina
    Constantin, Jorgete
    Salgueiro-Pagadigorria, Clairce Luzia
    Bazotte, Roberto Barbosa
    dos Santos Ferreira da Silva, Rui Sergio
    de Souza, Helenir Medri
    [J]. CELL BIOCHEMISTRY AND FUNCTION, 2008, 26 (03) : 320 - 328
  • [2] Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis
    Ding, Ming
    Bhupathiraju, Shilpa N.
    Chen, Mu
    van Dam, Rob M.
    Hu, Frank B.
    [J]. DIABETES CARE, 2014, 37 (02) : 569 - 586
  • [3] Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice
    Fujii, Yoshie
    Osaki, Noriko
    Hase, Tadashi
    Shimotoyodome, Akira
    [J]. JOURNAL OF NUTRITIONAL SCIENCE, 2015, 4
  • [4] Coffee and Green Tea As a Large Source of Antioxidant Polyphenols in the Japanese Population
    Fukushima, Yoichi
    Ohie, Takashi
    Yonekawa, Yasuhiko
    Yonemoto, Kohei
    Aizawa, Hiroki
    Mori, Yoko
    Watanabe, Makoto
    Takeuchi, Masato
    Hasegawa, Maiko
    Taguchi, Chie
    Kondo, Kazuo
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (04) : 1253 - 1259
  • [5] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
    Ishisaka, Akari
    Ichikawa, Satomi
    Sakakibara, Hiroyuki
    Piskula, Mariusz K.
    Nakamura, Toshiyuki
    Kato, Yoji
    Ito, Mikiko
    Miyamoto, Ken-ichi
    Tsuji, Akira
    Kawai, Yoshichika
    Terao, Junji
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2011, 51 (07) : 1329 - 1336
  • [6] Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice
    Jin, Shasha
    Chang, Cuiqing
    Zhang, Lantao
    Liu, Yang
    Huang, Xianren
    Chen, Zhimin
    [J]. PLOS ONE, 2015, 10 (04):
  • [7] Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
    Johnston, KL
    Clifford, MN
    Morgan, LM
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2003, 78 (04) : 728 - 733
  • [8] Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults
    Jokura, Hiroko
    Watanabe, Isamu
    Umeda, Mika
    Hase, Tadashi
    Shimotoyodome, Akira
    [J]. NUTRITION RESEARCH, 2015, 35 (10) : 873 - 881
  • [9] Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice
    Ma, Yongjie
    Gao, Mingming
    Liu, Dexi
    [J]. PHARMACEUTICAL RESEARCH, 2015, 32 (04) : 1200 - 1209
  • [10] Polyphenols:: food sources and bioavailability
    Manach, C
    Scalbert, A
    Morand, C
    Rémésy, C
    Jiménez, L
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 79 (05) : 727 - 747