Penetration of topically applied tacrolimus into the aqueous humor in Behcet's disease

被引：3

作者：

Yalcindag, F. Nilufer ^{[1
]}

Batioglu, Figen ^{[1
]}

Ozdemir, Ozden ^{[1
]}

机构：

[1] Ankara Univ, Fac Med, Dept Ophthalmol, TR-06100 Ankara, Turkey

来源：

ANNALS OF OPHTHALMOLOGY | 2007年 / 39卷 / 01期

关键词：

ENDOTOXIN-INDUCED UVEITIS; IMMUNOSUPPRESSIVE AGENT; POSTERIOR UVEITIS; FK506; FK-506; CYCLOSPORINE; RATS; STREPTOMYCES; REJECTION; INVITRO;

D O I：

10.1007/BF02697321

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behcet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0.3% every 6 hours for 3 days. The mean tacrolimus concentration in the aqueous and serum, as measured by microparticle enzyme immunoassay, were 12.49 and 0.76 ng/mL, respectively. Tacrolimus may be a promising treatment modality in anterior uveitis in Behcet's disease by topical application.

引用

页码：15 / 17

页数：3

共 16 条

[1] A GAMMA-SCINTIGRAPHIC EVALUATION OF MICROPARTICULATE OPHTHALMIC DELIVERY SYSTEMS - LIPOSOMES AND NANOPARTICLES [J].

FITZGERALD, P ;

HADGRAFT, J ;

KREUTER, J ;

WILSON, CG .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 40 (1-2) :81-84

[2] EFFECTS OF TOPICAL FK506 ON ENDOTOXIN-INDUCED UVEITIS (EIU) IN THE LEWIS RAT [J].

HIKITA, N ;

CHAN, CC ;

WHITCUP, SM ;

NUSSENBLATT, RB ;

MOCHIZUKI, M .

CURRENT EYE RESEARCH, 1995, 14 (03) :209-214

[3]

Hikita N, 1997, INVEST OPHTH VIS SCI, V38, P901

[4] FK506 TREATMENT OF NONINFECTIOUS UVEITIS [J].

ISHIOKA, M ;

OHNO, S ;

NAKAMURA, S ;

ISOBE, K ;

WATANABE, N ;

ISHIGATSUBO, Y ;

TANAKA, S .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1994, 118 (06) :723-729

[5]

KAWASHIMA H, 1988, INVEST OPHTH VIS SCI, V29, P1265

[6] Tacrolimus (FK506) in failed cyclosporin A therapy in endogenous posterior uveitis [J].

Kilmartin, DJ ;

Forrester, JV ;

Dick, AD .

OCULAR IMMUNOLOGY AND INFLAMMATION, 1998, 6 (02) :101-109

[7] FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES .2. IMMUNOSUPPRESSIVE EFFECT OF FK-506 INVITRO [J].

KINO, T ;

HATANAKA, H ;

MIYATA, S ;

INAMURA, N ;

NISHIYAMA, M ;

YAJIMA, T ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M ;

AOKI, H ;

OCHIAI, T .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1256-1265

[8] FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES .1. FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS [J].

KINO, T ;

HATANAKA, H ;

HASHIMOTO, M ;

NISHIYAMA, M ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M ;

AOKI, H ;

IMANAKA, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1249-1255

[9]

MILLS RA, 1995, CORNEA, V14, P157

[10]

MOCHIZUKI M, 1991, TRANSPL P, V23, P3343

← 1 2 →