Adverse Pregnancy Outcomes After Abnormal First-Trimester Screening for Aneuploidy

被引:21
作者
Goetzl, Laura [1 ]
机构
[1] Med Univ S Carolina, Dept Obstet & Gynecol, Div Maternal Fetal Med, Charleston, SC 29425 USA
关键词
First trimester screening; Congenital heart disease; Intrauterine growth restriction; Intrauterine fetal demise; INCREASED NUCHAL TRANSLUCENCY; PLASMA-PROTEIN-A; CHROMOSOMALLY NORMAL FETUSES; INTRAUTERINE GROWTH RESTRICTION; HUMAN CHORIONIC-GONADOTROPIN; FIRST-TRIMESTER DIAGNOSIS; EARLY PRENATAL-DIAGNOSIS; JARCHO-LEVIN-SYNDROME; FREE BETA-HCG; 1ST TRIMESTER;
D O I
10.1016/j.cll.2010.04.003
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Women with abnormal results of first trimester screening but with a normal karyotype are at risk for adverse pregnancy outcomes. A nuchal translucency of greater than 3.5 mm is associated with an increased risk of subsequent pregnancy loss, fetal infection, fetal heart abnormalities, and other structural abnormalities. Abnormal levels of first trimester analytes are also associated with adverse pregnancy outcomes, but the predictive value is less impressive. As a single marker, pregnancy-associated plasma protein (PAPP)-A level less than 1st percentile has a good predictive value for subsequent fetal growth restriction. Women with PAPP-A level less than 5th percentile should undergo subsequent risk assessment with routine maternal serum afetoprotein screening with the possible addition of uterine artery pulsatility index assessment in the midtrimester.
引用
收藏
页码:613 / +
页数:17
相关论文
共 106 条
[1]  
Achiron R, 2000, AM J MED GENET, V92, P159, DOI 10.1002/(SICI)1096-8628(20000529)92:3<159::AID-AJMG1>3.0.CO
[2]  
2-2
[3]   SCREENING FOR FETAL ANOMALIES DURING THE 1ST TRIMESTER OF PREGNANCY - TRANSVAGINAL VERSUS TRANSABDOMINAL SONOGRAPHY [J].
ACHIRON, R ;
TADMOR, O .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 1991, 1 (03) :186-191
[4]   Increased first trimester nuchal translucency: pregnancy and infant outcomes after routine screening for Down's syndrome in an unselected antenatal population [J].
Adekunle, O ;
Gopee, A ;
El-Sayed, M ;
Thilaganathan, B .
BRITISH JOURNAL OF RADIOLOGY, 1999, 72 (857) :457-460
[5]   Maternal plasma inhibin A at 11-13 weeks of gestation in hypertensive disorders of pregnancy [J].
Akolekar, Ranjit ;
Minekawa, Ryoko ;
Veduta, Alina ;
Romero, Ximena C. ;
Nicolaides, Kypros H. .
PRENATAL DIAGNOSIS, 2009, 29 (08) :753-760
[6]  
[Anonymous], ACOG PRACT B
[7]  
AZTEI A, 2005, ULTRASOUND OBST GYN, V26, P154
[8]   Increased nuchal translucency thickness and normal karyotype:: time for parental reassurance [J].
Bilardo, C. M. ;
Muller, M. A. ;
Pajkrt, E. ;
Clur, S. A. ;
Van Zalen, M. M. ;
Bijlsma, E. K. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2007, 30 (01) :11-18
[9]   Outcome of fetuses with enlarged nuchal translucency and normal karyotype [J].
Bilardo, CM ;
Pajkrt, E ;
de Graaf, I ;
Mol, BW ;
Bleker, OP .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 1998, 11 (06) :401-406
[10]   Outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation [J].
Brady, AF ;
Pandya, PP ;
Yuksel, B ;
Greenough, A ;
Patton, MA ;
Nicolaides, KH .
JOURNAL OF MEDICAL GENETICS, 1998, 35 (03) :222-224