Neural dysfunction during temporal discounting in paediatric Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder

被引:26
作者
Norman, Luke J. [1 ,2 ]
Carlisi, Christina O. [1 ]
Christakou, Anastasia [3 ]
Chantiluke, Kaylita [1 ]
Murphy, Clodagh [1 ,4 ,5 ]
Simmons, Andrew [6 ,7 ,8 ,9 ]
Giampietro, Vincent [6 ]
Brammer, Michael [6 ]
Mataix-Cols, David [10 ]
Rubia, Katya [1 ]
机构
[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, 16 De Crespigny Pk, London SE5 8AF, England
[2] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
[3] Univ Reading, Sch Psychol & Clin Language Sci, Ctr Integrat Neurosci & Neurodynam, Reading, Berks, England
[4] Kings Coll London, Sackler Inst Translat Neurodev, London, England
[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London, England
[6] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England
[7] Mental Hlth South London & Maudsley NHS Fdn Trust, BRC, NIHR, London, England
[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
[9] Karolinska Inst, Div Clin Geriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
[10] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
关键词
ADHD; OCD; fMRI; Discounting; Reward; Impulsivity; DEFICIT HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDER; DECISION-MAKING; SOCIOECONOMIC-STATUS; CHOICE-IMPULSIVITY; PREFRONTAL CORTEX; BRAIN ACTIVATION; ADHD; METAANALYSIS; DELAY;
D O I
10.1016/j.pscychresns.2017.09.008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Both Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are associated with choice impulsivity, i.e. the tendency to prefer smaller immediate rewards over larger delayed rewards. However, the extent to which this impulsivity is mediated by shared or distinct underlying neural mechanisms is unclear. Twenty-six boys with ADHD, 20 boys with OCD and 20 matched controls (aged 12-18) completed an fMRI version of an individually adjusted temporal discounting (TD) task which requires choosing between a variable amount of money now or 100 pound in one week, one month or one year. Activations to immediate and delayed reward choices were compared between groups using a three-way ANCOVA. ADHD patients had steeper discounting rates on the task relative to controls. OCD patients did not differ from controls or patients with ADHD. Patients with ADHD and OCD showed predominantly shared activation deficits during TD in frontostriato-insular-cerebellar regions responsible for self-control and temporal foresight, suggesting that choice impulsivity is mediated by overlapping neural dysfunctions in both disorders. OCD patients alone showed dysfunction relative to controls in right orbitofrontal and rostrolateral prefrontal cortex, extending previous findings of abnormalities in these regions in OCD to the domain of choice impulsiveness.
引用
收藏
页码:97 / 105
页数:9
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