HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer

被引:10
作者
Padua, Diana [1 ,2 ,3 ]
Pinto, Debora Filipa [1 ,2 ]
Figueira, Paula [1 ,2 ]
Pereira, Carlos Filipe [4 ,5 ,6 ]
Almeida, Raquel [1 ,2 ,7 ,8 ]
Mesquita, Patricia [1 ,2 ]
机构
[1] Univ Porto, I3S Inst Res & Innovat Hlth, P-4200135 Porto, Portugal
[2] Univ Porto, IPATIMUP Inst Mol Pathol & Immunol, P-4200465 Porto, Portugal
[3] Univ Porto, ICBAS Inst Biomed Sci Abel Salazar, P-4050313 Porto, Portugal
[4] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal
[5] Lund Univ, Cell Reprogramming Hematopoiesis & Immun Lab, Mol Med & Gene Therapy, Lund Stem Cell Ctr, BMC A12, S-22184 Lund, Sweden
[6] Lund Univ, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden
[7] Univ Porto, Fac Med, P-4200319 Porto, Portugal
[8] Univ Porto, Fac Sci, Dept Biol, P-4169007 Porto, Portugal
关键词
HMGA1; gastric cancer; prognosis; predictive value; chemotherapy; MOBILITY GROUP A1; EXPRESSION; OVEREXPRESSION; PROLIFERATION; HETEROGENEITY; METASTASIS; RESISTANCE; BIOMARKER; PROGNOSIS; PROTEINS;
D O I
10.3390/curroncol29010005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has been correlated with invasion, metastasis, and drug resistance, leading to worse patient survival. The aim of this work was to evaluate the clinical value of HMGA1 in gastric cancer. HMGA1 expression was analyzed by immunohistochemistry in a single hospital series (n = 323) of gastric adenocarcinoma cases (stages I to IV) with clinicopathological and treatment data. In this series, HMGA1 expression showed no significant relevance as a prognostic biomarker. Nevertheless, a significantly better overall survival was observed in cases with high levels of HMGA1 when they were treated with chemotherapy, compared to the nontreated ones, implying that they can benefit more from treatment than patients with low expression of HMGA1. We thereby show for the first time that HMGA1 expression has a substantial value as a biomarker of response to chemotherapy in gastric cancer.
引用
收藏
页码:56 / 67
页数:12
相关论文
共 47 条
[1]   HMGA1 Is Induced by Wnt/β-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer [J].
Akaboshi, Shin-ichi ;
Watanabe, Sugiko ;
Hino, Yuko ;
Sekita, Yoko ;
Xi, Yang ;
Araki, Kimi ;
Yamamura, Ken-ichi ;
Oshima, Masanobu ;
Ito, Takaaki ;
Baba, Hideo ;
Nakao, Mitsuyoshi .
AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (04) :1675-1685
[2]   An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].
Ben-Porath, Ittai ;
Thomson, Matthew W. ;
Carey, Vincent J. ;
Ge, Ruping ;
Bell, George W. ;
Regev, Aviv ;
Weinberg, Robert A. .
NATURE GENETICS, 2008, 40 (05) :499-507
[3]   Targeting transcription factors in cancer - from undruggable to reality [J].
Bushweller, John H. .
NATURE REVIEWS CANCER, 2019, 19 (11) :611-624
[4]   HMGA1 promoting gastric cancer oncogenic and glycolytic phenotypes by regulating c-myc expression [J].
Cao, X. P. ;
Cao, Y. ;
Zhao, H. ;
Yin, J. ;
Hou, P. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 516 (02) :457-465
[5]   MicroRNA let-7d-5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1 [J].
Chen, Yan-Nan ;
Ren, Chen-Chen ;
Yang, Li ;
Nai, Man-Man ;
Xu, Yi-Ming ;
Zhang, Feng ;
Liu, Yan .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2019, 54 (05) :1771-1784
[6]   HMGA1 protein overexpression in human breast carcinomas: Correlation with ErbB2 expression [J].
Chiappetta, G ;
Botti, G ;
Monaco, M ;
Pasquinelli, R ;
Pentimalli, F ;
Di Bonito, M ;
D'Aiuto, G ;
Fedele, M ;
Iuliano, R ;
Palmieri, EA ;
Pierantoni, GM ;
Giancotti, V ;
Fusco, A .
CLINICAL CANCER RESEARCH, 2004, 10 (22) :7637-7644
[7]   Binding of high mobility group A proteins to the mammalian genome occurs as a function of AT-content [J].
Colombo, Daniele F. ;
Burger, Lukas ;
Baubec, Tuncay ;
Schubeler, Dirk .
PLOS GENETICS, 2017, 13 (12)
[8]   The future of gastric cancer prevention [J].
Correa P. ;
Piazuelo M.B. ;
Camargo M.C. .
Gastric Cancer, 2004, 7 (1) :9-16
[9]   Critical role of HMGA proteins in cancer cell chemoresistance [J].
D'Angelo, Daniela ;
Mussnich, Paula ;
Arra, Claudio ;
Battista, Sabrina ;
Fusco, Alfredo .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (04) :353-360
[10]   High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs [J].
D'Angelo, Daniela ;
Mussnich, Paula ;
Rosa, Roberta ;
Bianco, Roberto ;
Tortora, Giampaolo ;
Fusco, Alfredo .
BMC CANCER, 2014, 14