A convenient synthesis of 5- and 6-substituted 2-phenyl-3H-pyrimidin-4-ones

被引：13

作者：

Zanatta, Nilo ^{[1
]}

Fantinel, Leonardo ^{[1
]}

Lourega, Rogerio V. ^{[1
]}

Bonacorso, Hello G. ^{[1
]}

Martins, Marcos A. P. ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

SYNTHESIS-STUTTGART | 2008年 / 03期

关键词：

pyrimidines; 2-phenylpyrimidin-4-ones; trichloromethylated enones; benzamidine hydrochloride; Sildenafil;

D O I：

10.1055/s-2008-1032032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient one-pot procedure for the synthesis of 5- and 6-substituted 2-phenyl-3H-pyrimidin-4-ones by the condensation of 4-alkoxy-1,1,1-trichloroalk-3-en-2-ones with benzamidine hydrochloride is described.

引用

页码：358 / 362

页数：5

共 27 条

[1] RUTHENIUM COMPLEX-CATALYZED SELECTIVE DEOXYGENATION OF AMIDOXIMES TO AMIDINES AND ITS APPLICATION TO THE FACILE SYNTHESIS OF PYRIMIDINES [J].

AKAZOME, M ;

KONDO, T ;

WATANABE, Y .

JOURNAL OF MOLECULAR CATALYSIS, 1993, 80 (03) :383-393

[2] ANIL-SYNTHESIS .23. PREPARATION OF STYRYL AND STILBENYL DERIVATIVES OF PYRIMIDINES [J].

BURDESKA, K ;

FUHRER, H ;

KABAS, G ;

SIEGRIST, AE .

HELVETICA CHIMICA ACTA, 1981, 64 (01) :113-152

[3] 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists [J].

Chang, LCW ;

Spanjersberg, RF ;

Künzel, JKV ;

Mulder-Krieger, T ;

van den Hout, G ;

Beukers, MW ;

Brussee, J ;

IJzerman, AP .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (26) :6529-6540

[4]

COLLA A, 1991, SYNTHESIS-STUTTGART, P483

[5]

GALLEMAERS JP, 1976, TETRAHEDRON LETT, P693

[6] Solid phase synthesis of dihydropyrimidinones and pyrimidinone carboxylic acids from malonic acid resin [J].

Hamper, BC ;

Gan, KZ ;

Owen, TJ .

TETRAHEDRON LETTERS, 1999, 40 (27) :4973-4976

[7]

HIRAI Y, 1983, HETEROCYCLES, V20, P1243

[8] REACTION OF 3-AMINOCROTONAMIDE WITH NITRILES [J].

KATO, T ;

CHIBA, T ;

SASAKI, M .

HETEROCYCLES, 1981, 16 (04) :577-580

[9] A C-13 NUCLEAR-MAGNETIC-RESONANCE STUDY OF THE PYRIMIDINE SYNTHESIS BY THE REACTIONS OF 1,3-DICARBONYL COMPOUNDS WITH AMIDINES AND UREAS [J].

KATRITZKY, AR ;

YOUSAF, TI .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1986, 64 (10) :2087-2093

[10]

KATRITZKY AR, 1999, TETRAHEDRON LETT, V40, P4973

← 1 2 3 →