Antibacterial and Antifungal Activities of Lectin Extracted from Fruiting Bodies of the Korean Cauliflower Medicinal Mushroom, Sparassis latifolia (Agaricomycetes)

被引：36
作者：
Chandrasekaran, Gayathri [1 ]
Lee, Young-Chul [2 ]
Park, Hyun [3 ]
Wu, Yuanzheng [1 ]
Shin, Hyun-Jae [1 ]
机构：
[1] Chosun Univ, Dept Biochem & Polymer Engn, Gwangju, South Korea
[2] Gachon Univ, Dept BioNano Technol, Songnam, Gyeonggi Do, South Korea
[3] Korea Forest Res Insititute, Seoul, South Korea
来源：
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | 2016年 / 18卷 / 04期
关键词：
antibacterial; antifungal; lectin; medicinal mushrooms; Sparassis latifolia; SEED LECTIN; IN-VITRO; CRISPA; STREPTOCOCCI; PURIFICATION; SPECIFICITY; BINDING; PROTEIN; MICE;
D O I：
10.1615/IntJMedMushrooms.v18.i4.20
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this article we describe the isolation and characterization of a novel lectin from fruiting bodies of the mushroom Sparassis latifolia. The antibacterial activity of the purified lectin against Escherichia coli and resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa as well as the antifungal activity against Candida and Fusarium species were determined. Circular dichroism spectroscopy and the tryptophan blue shift assay indicated that the lectin interacts with microbial surfaces. This suggests the potential of the lectin isolated from S. latifolia, a valuable source of bioactive constituents, as a therapeutic in pharmaceutical agent.
引用
收藏
页码：291 / 299
页数：9
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