MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis

被引：14

作者：

Clarke, Laura ^{[1
]}

Arnett, Simon ^{[1
]}

Bukhari, Wajih ^{[1
]}

Khalilidehkordi, Elham ^{[1
]}

Sanchez, Sofia Jimenez ^{[1
]}

O'Gorman, Cullen ^{[1
]}

Sun, Jing ^{[1
]}

Prain, Kerri M. ^{[2
]}

Woodhall, Mark ^{[3
]}

Silvestrini, Roger ^{[4
]}

Bundell, Christine S. ^{[5
]}

Abernethy, David A. ^{[6
]}

Bhuta, Sandeep ^{[1
]}

Blum, Stefan ^{[7
]}

Boggild, Mike ^{[8
]}

Boundy, Karyn ^{[9
]}

Brew, Bruce J. ^{[10
]}

Brownlee, Wallace ^{[11
]}

Butzkueven, Helmut ^{[12
]}

Carroll, William M. ^{[13
]}

Chen, Cella ^{[14
]}

Coulthard, Alan ^{[15
]}

Dale, Russell C. ^{[16
]}

Das, Chandi ^{[17
]}

Fabis-Pedrini, Marzena J. ^{[13
]}

Gillis, David ^{[15
]}

Hawke, Simon ^{[18
]}

Heard, Robert ^{[16
]}

Henderson, Andrew P. D. ^{[19
]}

Heshmat, Saman ^{[1
]}

Hodgkinson, Suzanne ^{[20
]}

Kilpatrick, Trevor J. ^{[21
]}

King, John ^{[22
]}

Kneebone, Christopher ^{[23
]}

Kornberg, Andrew J. ^{[24
]}

Lechner-Scott, Jeannette ^{[25
]}

Lin, Ming-Wei ^{[18
]}

Lynch, Christopher ^{[26
]}

Macdonell, Richard A. L. ^{[27
]}

Mason, Deborah F. ^{[28
]}

McCombe, Pamela A. ^{[29
]}

Pereira, Jennifer ^{[26
]}

Pollard, John D. ^{[18
]}

Ramanathan, Sudarshini ^{[30
,31
]}

Reddel, Stephen W. ^{[16
]}

Shaw, Cameron P. ^{[32
]}

Spies, Judith M. ^{[18
]}

Stankovich, James ^{[33
]}

Sutton, Ian ^{[34
]}

Vucic, Steve ^{[19
]}

机构：

[1] Griffith Univ, Menzies Hlth Inst Queensland, Southport, Qld, Australia

[2] Pathol Queensland, Dept Immunol, Royal Brisbane & Womens Hosp, Herston, Qld, Australia

[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

[4] Westmead Hosp, Dept Immunopathol, Westmead, NSW, Australia

[5] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA, Australia

[6] Wellington Hosp, Dept Neurol, Newtown, New Zealand

[7] Princess Alexandra Hosp, Dept Neurol, Woolloongabba, Qld, Australia

[8] Townsville Hosp, Dept Neurol, Douglas, Qld, Australia

[9] Flinders Univ S Australia, Dept Neurol, Coll Med & Publ Hlth, Bedford Pk, SA, Australia

[10] Univ New South Wales, St Vincents Hosp, Ctr Appl Med Res, Darlinghurst, NSW, Australia

[11] Auckland City Hosp, Dept Neurol, Grafton, New Zealand

[12] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Parkville, Vic, Australia

[13] Univ Western Australia, Ctr Neuromuscular & Neurol Disorders, Queen Elizabeth II Med Ctr, Perron Inst Neurol & Translat Sci, Nedlands, WA, Australia

[14] Flinders Univ S Australia, Flinders Med Ctr, Dept Ophthalmol, Bedford Pk, SA, Australia

[15] Univ Queensland, Royal Brisbane & Womens Hosp, Sch Med, Herston, Qld, Australia

[16] Univ Sydney, Brain & Mind Ctr, Camperdown, NSW, Australia

[17] Canberra Hosp, Dept Neurol, Garran, ACT, Australia

[18] Univ Sydney, Royal Prince Alfred Hosp, Sydney Med Sch, Camperdown, NSW, Australia

[19] Westmead Hosp, Dept Neurol, Westmead, NSW, Australia

[20] Univ New South Wales, Liverpool Hosp, South Western Sydney Med Sch, Liverpool, NSW, Australia

[21] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[22] Royal Melbourne Hosp, Dept Neurol, Parkville, Vic, Australia

[23] Royal Adelaide Hosp, Dept Neurol, Adelaide, SA, Australia

[24] Univ Melbourne, Royal Childrens Hosp, Sch Paediat, Parkville, Vic, Australia

[25] Univ Newcastle, Hunter Med Res Inst, New Lambton Hts, NSW, Australia

[26] Univ Auckland, Sch Med, Grafton, New Zealand

[27] Austin Hlth, Dept Neurol, Heidelberg, Vic, Australia

[28] Christchurch Hosp, Dept Neurol, Christchurch, New Zealand

[29] Univ Queensland, Royal Brisbane & Womens Hosp, Ctr Clin Res, Herston, Qld, Australia

[30] Univ Sydney, Childrens Hosp Westmead, Kids Neurosci Ctr, Neuroimmunol Grp, Westmead, NSW, Australia

[31] Concord Repatriat Gen Hosp, Dept Neurol, Concord, NSW, Australia

[32] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia

[33] Univ Tasmania, Menzies Res Inst, Hobart, Tas, Australia

[34] St Vincents Hosp, Dept Neurol, Darlinghurst, NSW, Australia

[35] Gold Coast Univ Hosp, Dept Neurol, Southport, Qld, Australia

来源：

FRONTIERS IN NEUROLOGY | 2021年 / 12卷

关键词：

neuromyelitis optica; multiple sclerosis; magnetic resonance imaging; diagnosis; NMOSD; EXTENSIVE TRANSVERSE MYELITIS; RESONANCE-IMAGING FINDINGS; SPINAL-CORD LESIONS; INFLAMMATORY DEMYELINATING DISORDERS; REVERSIBLE ENCEPHALOPATHY SYNDROME; CLINICALLY ISOLATED SYNDROMES; BRAIN ABNORMALITIES; FOLLOW-UP; PREDICT CONVERSION; MATTER INVOLVEMENT;

D O I：

10.3389/fneur.2021.722237

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), "bright spotty" (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS.

引用

页数：24

共 132 条

[1] There is less MRI brain lesions and no characteristic MRI Brain findings in IIDDs patients with positive AQP4 serology among Malaysians
Abdullah, Suhailah
Fadzli, Farhana
Ramli, Norlisah
Tan, Chong Tin
[J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2017, 12 : 34 - 38
[2] Paediatric neuromyelitis optica: clinical, MRI of the brain and prognostic features
Absoud, Michael
Lim, Ming J.
Appleton, Richard
Jacob, Anu
Kitley, Joanna
Leite, M. Isabel
Pike, Michael G.
Vincent, Angela
Wassmer, Evangeline
Waters, Patrick
Woodhall, Mark
Hemingway, Cheryl
Palace, Jacqueline
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2015, 86 (04) : 470 - +
[3] Recurrent neuromyelitis optica in Brazilian patients: clinical, immunological, and neuroimaging characteristics
Adoni, T.
Lino, A. M. M.
da Gama, P. D.
Apostolos-Pereira, S. L.
Marchiori, P. E.
Kok, F.
Callegaro, D.
[J]. MULTIPLE SCLEROSIS JOURNAL, 2010, 16 (01) : 81 - 86
[4] ON ESTIMATING BINOMIAL RESPONSE RELATIONS
ANSCOMBE, FJ
[J]. BIOMETRIKA, 1956, 43 (3-4) : 461 - 464
[5] Modifications of longitudinally extensive transverse myelitis and brainstem lesions in the course of neuromyelitis optica (NMO): a population-based, descriptive study
Asgari, Nasrin
Skejoe, Hanne Pernille Bro
Lillevang, Soeren Thue
Steenstrup, Troels
Stenager, Egon
Kyvik, Kirsten Ohm
[J]. BMC NEUROLOGY, 2013, 13
[6] Clinical outcomes and predictive factors related to good outcomes in plasma exchange in severe attack of NMOSD and long extensive transverse myelitis: Case series and review of the literature
Aungsumart, Saharat
Apiwattanakul, Metha
[J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2017, 13 : 93 - 97
[7] Magnetic resonance imaging findings in 22 cases of myelitis: comparison between patients with and without multiple sclerosis
Bakshi, R
Kinkel, PR
Mechtler, LL
Bates, VE
Lindsay, BD
Esposito, SE
Kinkel, WR
[J]. EUROPEAN JOURNAL OF NEUROLOGY, 1998, 5 (01) : 35 - 48
[8] Pencil-thin ependymal enhancement in neuromyelitis optica spectrum disorders
Banker, Piyush
Sonni, Smitha
Kister, Ilya
Loh, John P.
Lui, Yvonne W.
[J]. MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (07) : 1050 - 1053
[9] A clinical and radiological profile of neuromyelitis optica and spectrum disorders in an Indian cohort
Barhate, Kavita Sohan
Ganeshan, Malti
Sen Singhal, Bhim
[J]. ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2014, 17 (01) : 77 - 81
[10] Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis
Barkhof, F
Filippi, M
Miller, DH
Scheltens, P
Campi, A
Polman, CH
Comi, G
Ader, HJ
Losseff, N
Valk, J
[J]. BRAIN, 1997, 120 : 2059 - 2069

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