Mucoadhesive beads of gliclazide: Design, development, and evaluation

被引:48
|
作者
Nayak, Amit Kumar [3 ]
Hasnain, M. Saquib [2 ]
Beg, Sarwar [1 ]
Alam, M. Intakhab [1 ]
机构
[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut, New Delhi 1100062, India
[2] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut Chem, Mayurbhanj 757086, Orissa, India
[3] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Orissa, India
来源
SCIENCEASIA | 2010年 / 36卷 / 04期
关键词
mucoadhesion; bioadhesion; alginate-ispaghula; cross-linking; IN-VIVO; DRUG-DELIVERY; MICROSPHERES; ALGINATE; EFFICACY; CHITOSAN; VITRO; MICROPARTICLES; AMOXICILLIN; ABSORPTION;
D O I
10.2306/scienceasia1513-1874.2010.36.319
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Novel mucoadhesive beads were developed and evaluated for oral controlled release of the hypoglycaemic agent gliclazide. Various formulations of mucoadhesive beads were prepared using two different natural polymers, alginate and ispaghula, in various stoichiometric proportions with CaCl2 as a source of counter ions. The mucoadhesive beads were characterized for entrapment efficiency, particle size, surface morphology, and swelling index. The kinetics of drug release and their mucoadhesive nature in vitro using goat intestinal mucosa was also investigated at various physiological pH conditions. The effects of various proportions of the two polymers along with the effect of various percentages of counter ions on mucoadhesion property, size; entrapment efficiency, and drug release behaviour were studied. The effective mucoadhesion property with sustained release profile was observed from optimized mucoadhesive beads consisting of alginate and ispaghula husk (1:1) and polymer (2:1) with 5-10% w/v counter ions (CaCl2). These formulations showed optimum mucoadhesion behaviour having more than 70% w/v of drug entrapment and particle sizes of 896.7 +/- 0.8 and 920.6 +/- 1.2 mu m, respectively.
引用
收藏
页码:319 / 325
页数:7
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