Morphological changes of radial glial cells during mouse embryonic development

被引：9

作者：

Lu, Xi ^{[1
]}

Duan, Minghui ^{[1
]}

Song, Lingzhen ^{[1
]}

Zhang, Wei ^{[1
]}

Hu, Xinde ^{[1
]}

Zhao, Shanting ^{[1
]}

Chen, Shulin ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

来源：

BRAIN RESEARCH | 2015年 / 1599卷

基金：

中国国家自然科学基金;

关键词：

Radial glial cell; Glial branch; Neuronal migration; In utero electroporation; CORTICAL VENTRICULAR ZONE; NEURONAL MIGRATION; CEREBRAL-CORTEX; DENTATE GYRUS; GENE-TRANSFER; REELIN; ELECTROPORATION; INTEGRIN; SCAFFOLD; ORIENTATION;

D O I：

10.1016/j.brainres.2014.12.039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During brain development, the radial glial cell acts as a scaffold to support radial migration of postmitotic neurons. However, the morphological changes of radial glial cells during embryo development are poorly understood. We used in utero electroporation and immunohistochemistry to study the dynamics of radial glial cells accompanied by cortical development in mice from embryonic day 14 to postnatal day 0. We found that different segments of radial glial cells changed by the growth of different layers of cortex, such as marginal zone, cortical plate, intermediate zone and ventricular zone. Moreover, the length, angle and number of branches of the radial glial cell changed significantly at the late stage of neurogenesis. All these changes were consistent with the distinct phases of locomotion. Thus, we speculated that morphological changes of the radial glial cell were associated with the neuronal migration and dendritic development. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：57 / 66

页数：10

共 30 条

[1] Radial glia serve as neuronal progenitors in all regions of the central nervous system
Anthony, TE
Klein, C
Fishell, G
Heintz, N
[J]. NEURON, 2004, 41 (06) : 881 - 890
[2] Distinct functions of α3 and αv integrin receptors in neuronal migration and laminar organization of the cerebral cortex
Anton, ES
Kreidberg, JA
Rakic, P
[J]. NEURON, 1999, 22 (02) : 277 - 289
[3] Reelin Induces Branching of Neurons and Radial Glial Cells during Corticogenesis
Chai, Xuejun
Fan, Li
Shao, Hong
Lu, Xi
Zhang, Wei
Li, Jiawei
Wang, Jianlin
Chen, Shulin
Frotscher, Michael
Zhao, Shanting
[J]. CEREBRAL CORTEX, 2015, 25 (10) : 3640 - 3653
[4] A mechanism for inside-out lamination in the neocortex
Cooper, Jonathan A.
[J]. TRENDS IN NEUROSCIENCES, 2008, 31 (03) : 113 - 119
[5] Reelin binds α3β1 integrin and inhibits neuronal migration
Dulabon, L
Olson, EC
Taglienti, MG
Eisenhuth, S
McGrath, B
Walsh, CA
Kreidberg, JA
Anton, ES
[J]. NEURON, 2000, 27 (01) : 33 - 44
[6] FENG L, 1995, DEVELOPMENT, V121, P1719
[7] REELIN, NEURONAL POLARITY AND PROCESS ORIENTATION OF CORTICAL NEURONS
Foerster, E.
[J]. NEUROSCIENCE, 2014, 269 : 102 - 111
[8] Reelin, Disabled 1, and β1 integrins are required for the formation of the radial glial scaffold in the hippocampus
Förster, E
Tielsch, A
Saum, B
Weiss, KH
Johanssen, C
Graus-Porta, D
Müller, U
Frotscher, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) : 13178 - 13183
[9] Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold
Frotscher, M
Haas, CA
Förster, E
[J]. CEREBRAL CORTEX, 2003, 13 (06) : 634 - 640
[10] RETROVIRALLY INTRODUCED ANTISENSE INTEGRIN RNA INHIBITS NEUROBLAST MIGRATION INVIVO
GALILEO, DS
MAJORS, J
HORWITZ, AF
SANES, JR
[J]. NEURON, 1992, 9 (06) : 1117 - 1131

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