Overcoming obstacles to developing new analgesics

被引：166

作者：

Woolf, Clifford J. ^{[1
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机构：

[1] Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[2] Childrens Hosp, Program Neurobiol, Dept Neurol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 11期

基金：

美国国家卫生研究院;

关键词：

TRIALS IMMPACT RECOMMENDATIONS; OF-FUNCTION MUTATIONS; CHRONIC PAIN; NEUROPATHIC PAIN; CENTRAL SENSITIZATION; GTP CYCLOHYDROLASE; PLACEBO ANALGESIA; SODIUM-CHANNEL; IN-VIVO; PREGABALIN;

D O I：

10.1038/nm.2230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite substantial investment by the pharmaceutical industry over several decades, there has been little progress in developing new, efficacious and safe analgesics. As a result, many large pharmaceutical companies are leaving the area of pain medication. Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging.

引用

页码：1241 / 1247

页数：7

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