Effect of NFE2L2 Genetic Polymorphism on the Association Between Oral Estrogen Therapy and the Risk of Venous Thromboembolism in Postmenopausal Women

被引：21

作者：

Bouligand, J. ^{[1
,2
]}

Cabaret, O. ^{[1
]}

Canonico, M. ^{[3
,4
]}

Verstuyft, C. ^{[1
,5
]}

Dubert, L. ^{[5
]}

Becquemont, L. ^{[1
,5
]}

Guiochon-Mantel, A. ^{[1
,2
,4
]}

Scarabin, P. Y. ^{[3
]}

机构：

[1] Univ Paris Sud, Hop Bicetre, AP HP, Lab Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, France

[2] Univ Paris Sud, INSERM, U693, F-94275 Le Kremlin Bicetre, France

[3] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Villejuif, France

[4] Univ Paris Sud, UMRS 1018, Villejuif, France

[5] Univ Paris Sud, Dept Pharmacol, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 01期

关键词：

ANTIOXIDANT RESPONSE ELEMENT; TRANSCRIPTION FACTOR NRF2; REPLACEMENT THERAPY; OXIDATIVE STRESS; HORMONE-THERAPY; CONSENSUS SEQUENCE; ACTIVATION; IDENTIFICATION; INFLAMMATION; EXPRESSION;

D O I：

10.1038/clpt.2010.241

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oral, but not transdermal, estrogen therapy increases the risk of venous thromboembolism (VTE) in women who are past menopause. Data from the Estrogen and Thromboembolism Risk (ESTHER) study were used to investigate the effects of the genetic polymorphism of NFE2L2 rs6721961, which may impair Nrf2-dependent hepatic conjugation of estrogen metabolites. As compared with nonusers, the odds ratio (OR) for VTE in current users of oral estrogens was 2.5 (95% confidence interval (CI): 1.3-4.8) in patients with wildtype NFE2L2 and 17.9 (95% CI: 3.7-85.7) in those with the polymorphism (interaction, P = 0.01).

引用

页码：60 / 64

页数：5

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