QSAR of chemical polarizability and nerve toxicity. 2

被引：28

作者：

Hansch, C ^{[1
]}

Kurup, A ^{[1
]}

机构：

[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA

来源：

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 2003年 / 43卷 / 05期

关键词：

D O I：

10.1021/ci030289e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polarizability is a property of molecules that has long been of interest to scientists from a variety of viewpoints. However, in the area of the QSAR of chemical-biological interactions, it has received little attention. Recently we have shown that one can use the simple summation of the valence electrons (H = 1, C = 4, 0 = 6, etc.) in a molecule as a measure of its polarizability. We have found this parameter to correlate nerve toxicity of a wide variety of chemicals acting on nerves of frogs, rabbits, cockroaches, and humans.

引用

页码：1647 / 1651

页数：5

共 21 条

[1] ACTION OF ANESTHETICS ON EXCITABLE MEMBRANES - A QUANTUM-CHEMICAL ANALYSIS [J].