New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory

被引：0
作者：
Pinheiro Macedo, Clovis Ney [1 ]
Silva Braga, Francisco Evanilso [2 ]
Bomfim Soares Campelo, Ana Paula [3 ]
Diniz, Gabriel Maia [2 ]
de Franca Lopes, Luiz Gonzaga [4 ]
Kubrusly, Marcos [2 ]
Soares Campelo, Marcio Wilker [2 ]
机构：
[1] Ctr Univ Christus UNICHRISTUS, Med Sch, Postgrad Program Minimally Invas Technol & Hlth S, Fortaleza, Ceara, Brazil
[2] UNICHRISTUS, Med Sch, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Dept Surg, Fortaleza, Ceara, Brazil
[4] Univ Fed Ceara, Chem Dept, Fortaleza, Ceara, Brazil
来源：
ACTA CIRURGICA BRASILEIRA | 2019年 / 34卷 / 12期
关键词：
Anti-Inflammatory Agents; Non-Steroidal; Kidney; Ruthenium; Rats; NITRIC-OXIDE DONORS; RUTHENIUM COMPLEXES; NEPHROTIC SYNDROME; ISCHEMIA; DRUGS; LACUNARITY; INHIBITORS; MELOXICAM; SYNTHASE; SYSTEMS;
D O I：
10.1590/s0102-865020190120000001
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Purpose: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results: At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6%) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion: Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
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页数：8
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