Successive emergence of Enterobacter aerogenes strains resistant to imipenem and colistin in a patient

被引：63
作者：
Thiolas, A
Bollet, C
La Scola, B
Raoult, D
Pagès, JM
机构：
[1] Univ Mediterranee, Fac Med, IFR48, EA2197, F-13385 Marseille, France
[2] Univ Mediterranee, Enveloppe Bacterienne Permeabil & Antibiot, EA2197, F-13385 Marseille, France
[3] Univ Mediterranee, Unite Rickettsies, CNRS, UMR6020, F-13385 Marseille, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期
关键词：
D O I：
10.1128/AAC.49.4.1354-1358.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Enterobacter aerogenes is an agent of hospital-acquired infection that exhibits a remarkable resistance to beta-lactam antibiotics during therapy. Five successive isolates of E. aerogenes infecting a patient and exhibiting a multiresistance phenotype to beta-lactam antibiotics and fluoroquinollones were investigated. Among these clinical strains, four presented resistant phenotypes during successive imipenem and colistin treatments. The involved resistance mechanisms exhibited by the successive isolates were associated with alterations of the outer membrane that caused a porin decrease and lipopolysaccharide modifications.
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页码：1354 / 1358
页数：5
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