The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

被引：291

作者：

Hayashi, Y ^{[1
]}

Tsuboi, W

Ashimine, I

Urushima, T

Shoji, M

Sakai, K

机构：

[1] Sci Univ Tokyo, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1628601, Japan

[2] Sci Univ Tokyo, Dept Appl Chem, Fac Sci, Shinjuku Ku, Tokyo 1628601, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 31期

关键词：

aldehydes; asymmetric synthesis; enantioselectivity; organocatalysts; three-component reaction;

D O I：

10.1002/anie.200351813

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).

引用

页码：3677 / 3680

页数：4

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