The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

被引：291
|
作者：
Hayashi, Y [1 ]
Tsuboi, W
Ashimine, I
Urushima, T
Shoji, M
Sakai, K
机构：
[1] Sci Univ Tokyo, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1628601, Japan
[2] Sci Univ Tokyo, Dept Appl Chem, Fac Sci, Shinjuku Ku, Tokyo 1628601, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 31期
关键词：
aldehydes; asymmetric synthesis; enantioselectivity; organocatalysts; three-component reaction;
D O I：
10.1002/anie.200351813
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).
引用
收藏
页码：3677 / 3680
页数：4
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