The dawning of a 'Golden era' in lantibiotic bioengineering

被引：68
作者：
Field, Des [1 ]
Hill, Colin [1 ,2 ]
Cotter, Paul D. [2 ,3 ]
Ross, R. Paul [2 ,3 ]
机构：
[1] Univ Coll Cork, Dept Microbiol, Cork, Ireland
[2] Alimentary Pharmabiot Ctr, Cork, Ireland
[3] Teagasc Food Res Ctr, Fermoy, Co Cork, Ireland
来源：
MOLECULAR MICROBIOLOGY | 2010年 / 78卷 / 05期
关键词：
RESISTANT STAPHYLOCOCCUS-AUREUS; SITE-DIRECTED MUTAGENESIS; IN-VITRO RECONSTITUTION; ANTIMICROBIAL ACTIVITY; LACTICIN; 3147; LIPID-II; POSTTRANSLATIONAL MODIFICATION; OXIDATIVE DECARBOXYLATION; SUBSTRATE-SPECIFICITY; EXPRESSION SYSTEM;
D O I：
10.1111/j.1365-2958.2010.07406.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P>There are many examples of highly modified antimicrobial peptides in nature, many of which are non-ribosomally synthesized. However, the bacterial lantibiotics are produced as gene-encoded pre-peptides that are subsequently modified by dedicated enzyme systems to form extraordinarily potent inhibitors. Consequently, they are much more amenable to bioengineering which could lead to the generation of a new arsenal of potent antimicrobials. However, although bioengineering of these compounds has been underway for at least two decades, significant progress has only been reported in recent years. This review charts these recent developments which suggest that we are entering a 'Golden era' of lantibiotic bioengineering.
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收藏
页码：1077 / 1087
页数：11
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