Therapeutic potential of PPARγ natural agonists in liver diseases

被引：91
作者：
Wu, Liwei [1 ,2 ]
Guo, Chuanyong [1 ,2 ]
Wu, Jianye [1 ]
机构：
[1] Tongji Univ, Putuo Peoples Hosp, Dept Gastroenterol, Sch Med, Shanghai 200072, Peoples R China
[2] Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastroenterol, Sch Med, Shanghai, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 05期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
liver diseases; natural agonists; PPAR gamma; ACTIVATED-RECEPTOR-GAMMA; HEPATIC STELLATE CELLS; INDUCED INSULIN-RESISTANCE; BETA-AMYLOID GENERATION; NF-KAPPA-B; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; IN-VITRO; 3T3-L1; ADIPOCYTES;
D O I：
10.1111/jcmm.15028
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPAR gamma plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver and tumours. Natural products are a promising pool for drug discovery, and enormous research effort has been invested in exploring the PPAR gamma-activating potential of natural products. In this manuscript, we will review the research progress of PPAR gamma agonists from natural products in recent years and probe into the application potential and prospects of PPAR gamma natural agonists in the therapy of various liver diseases, including inflammation, hepatic fibrosis, non-alcoholic fatty liver and liver cancer.
引用
收藏
页码：2736 / 2748
页数：13
相关论文
共 203 条
[11]   Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic rats [J].
Balakrishnan, Brindha Banu ;
Krishnasamy, Kalaivani ;
Choi, Ki Choon .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 103 :719-728
[12]   PPAR dual agonists: Are they opening Pandora's box? [J].
Balakumar, Pitchal ;
Rose, Madhankumar ;
Ganti, Subrahmanya S. ;
Krishan, Pawan ;
Singh, Manjeet .
PHARMACOLOGICAL RESEARCH, 2007, 56 (02) :91-98
[13]   Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats [J].
Banu, Balakrishnan Brindha ;
Kalaivani, Krishnasamy ;
Vijayakumar, Mayakrishnan ;
Arokiyaraj, Selvaraj .
BIOMEDICINE & PHARMACOTHERAPY, 2019, 112
[14]   Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder [J].
Barone, Rita ;
Rizzo, Renata ;
Tabbi, Giovanni ;
Malaguarnera, Michele ;
Frye, Richard E. ;
Bastin, Jean .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (08)
[15]  
Beekmann K, 2015, FOOD FUNCT, V6, P1098, DOI [10.1039/c5fo00076a, 10.1039/C5FO00076A]
[16]   Terminalia arjuna prevents Interleukin-18-induced atherosclerosis via modulation of NF-κB/PPAR-γ-mediated pathway in Apo E-/- mice [J].
Bhat, Owais Mohammad ;
Kumar, P. Uday ;
Rao, K. Rajender ;
Ahmad, Ashfaq ;
Dhawan, Veena .
INFLAMMOPHARMACOLOGY, 2018, 26 (02) :583-598
[17]   Molecular Targets of Cannabidiol in Neurological Disorders [J].
Bih, Clementino Ibeas ;
Chen, Tong ;
Nunn, Alistair V. W. ;
Bazelot, Michael ;
Dallas, Mark ;
Whalley, Benjamin J. .
NEUROTHERAPEUTICS, 2015, 12 (04) :699-730
[18]   The Role of PPARγ in Hepatocellular Carcinoma [J].
Borbath, Ivan ;
Horsmans, Yves .
PPAR RESEARCH, 2008, 2008
[19]   Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle [J].
Camirand, A ;
Marie, V ;
Rabelo, R ;
Silva, JE .
ENDOCRINOLOGY, 1998, 139 (01) :428-431
[20]   Cannabidiol, neuroprotection and neuropsychiatric disorders [J].
Campos, Alline C. ;
Fogaca, Manoela V. ;
Sonego, Andreza B. ;
Guimaraes, Francisco S. .
PHARMACOLOGICAL RESEARCH, 2016, 112 :119-127
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