Therapeutic potential of PPARγ natural agonists in liver diseases

被引：91
作者：
Wu, Liwei [1 ,2 ]
Guo, Chuanyong [1 ,2 ]
Wu, Jianye [1 ]
机构：
[1] Tongji Univ, Putuo Peoples Hosp, Dept Gastroenterol, Sch Med, Shanghai 200072, Peoples R China
[2] Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastroenterol, Sch Med, Shanghai, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 05期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
liver diseases; natural agonists; PPAR gamma; ACTIVATED-RECEPTOR-GAMMA; HEPATIC STELLATE CELLS; INDUCED INSULIN-RESISTANCE; BETA-AMYLOID GENERATION; NF-KAPPA-B; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; IN-VITRO; 3T3-L1; ADIPOCYTES;
D O I：
10.1111/jcmm.15028
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPAR gamma plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver and tumours. Natural products are a promising pool for drug discovery, and enormous research effort has been invested in exploring the PPAR gamma-activating potential of natural products. In this manuscript, we will review the research progress of PPAR gamma agonists from natural products in recent years and probe into the application potential and prospects of PPAR gamma natural agonists in the therapy of various liver diseases, including inflammation, hepatic fibrosis, non-alcoholic fatty liver and liver cancer.
引用
收藏
页码：2736 / 2748
页数：13
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