Synergistic interactions between 12-0-tetradecanoylphorbol-13-acetate (TPA) and imatinib in patients with chronic myeloid leukemia in blastic phase that is resistant to standard-dose imatinib

被引：8
作者：
Fang, Baijun
Song, Yongping
Han, Zhengtao
Wei, Xudong
Lin, Quande
Zhu, Xiaoxiu
Yang, Ruyu
Sun, Junzhong
Tian, Guofeng
Liu, Xinjian
Cao, Guoshun
Shi, Yin
Nie, Neng
Li, Dapeng
Zhao, Robert Chunhua
机构：
[1] Henan Med Univ, Henan Tumor Hosp, Henan Med Sch, Henan Inst Haematol, Zhengzhou 450008, Peoples R China
[2] Cent Hosp, Nanyang, Peoples R China
[3] Peoples Hosp Nanyang 1, Nanyang, Peoples R China
[4] Xinhua Hosp, Pingdingshan, Peoples R China
[5] Chinese Acad Med Sci, Blood Dis Hosp, Inst Haematol, Tianjin, Peoples R China
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 10期
关键词：
chronic myelogenous leukemia; blastic phase; 12-0-tetradecanoylphorbol-13-acetate; imatinib; resistant;
D O I：
10.1016/j.leukres.2007.02.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have demonstrated that 12-0-tetradecanoylphorbol-13-acetate (TPA) combined with vitamin D-3 (VD3) and cytosine arabinoside (Ara C) is effective and feasible for chronic myelogenous leukemia (CML) in blastic phase (BP). In the current study, the efficacy of TPA combined with inhibitor imatinib mesylate (imatinib) was investigated in patients with CML in BP that was resistant to standard-dose imatinib (400 mg/day). The results suggested that TPA combined with imatinib (400 mg/day) might overcome disease-poor response to conventional doses. So this approach deserves further evaluation as frontline therapy for newly diagnosed CML. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1441 / 1444
页数：4
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