Cell transformation by light charged particles: review of available data

被引：7
作者：
Bettega, D
机构：
[1] Univ Milan, Dipartimento Fis, I-20133 Milan, Italy
[2] Ist Nazl Fis Nucl, I-20133 Milan, Italy
来源：
RADIOTHERAPY AND ONCOLOGY | 2004年 / 73卷
关键词：
in vitro transformation; charged particles; relative biological effectiveness; dose protraction effects;
D O I：
10.1016/S0167-8140(04)80039-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Data reported in the literature on neoplastic transformation induced in cultured cells by light charged particles are compared and analyzed as a function of LET and dose protraction. Light charged particles RBE for transformation is maximum between 75 and 120 keV/mu m. The majority of the data suggest that RBE values for survival and transformation are of similar magnitude. Dose protraction effects on transformation induction depend on dose, dose rate and on radiation quality.
引用
收藏
页码：S155 / S157
页数：3
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