α-Synuclein in Parkinson's disease and advances in detection

被引：46
作者：
Chen, Rong [1 ]
Gu, Xuan [2 ]
Wang, Xiaoying [2 ]
机构：
[1] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China
[2] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing 210009, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2022年 / 529卷
基金：
中国国家自然科学基金;
关键词：
Alpha-synuclein; Parkinson's disease; Pathogenic process; Detection method; Biosensor; FLUORESCENT-PROBE; MITOCHONDRIAL; TRANSMISSION; PATHOGENESIS; DYSFUNCTION;
D O I：
10.1016/j.cca.2022.02.006
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Parkinson's disease (PD) is a threatening neurodegenerative disorder that seriously affects patients' life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (alpha-Syn) to PD. alpha-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic process of alpha-Syn based on recent researches, outlines and compares commonly used analysis and detection technologies of alpha-Syn. Specifically, the detection of alpha-Syn by new electrochemical, photochemical, and crystal biosensors is mainly examined. Furthermore, the speculation of future study orientation is discussed, which provides reference for the further research and application of alpha-Syn as biomarker.
引用
收藏
页码：76 / 86
页数：11
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