Precision Medicine in Rheumatoid Arthritis

被引：34

作者：

Bluett, James ^{[1
]}

Barton, Anne ^{[1
,2
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Arthrit Res UK Ctr Genet & Genom, Div Musculoskeletal & Dermal Sci,Ctr Musculoskele, Room 2-607,Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England

[2] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester M139WU, Lancs, England

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2017年 / 43卷 / 03期

基金：

英国医学研究理事会;

关键词：

Methotrexate; Anti-TNF; Anti-TNF response; Genetic; Genomic; Rheumatoid arthritis; Pharmacogenomics; ANTI-TNF TREATMENT; TREATMENT RESPONSE; ALPHA PRODUCTION; BRITISH SOCIETY; METHOTREXATE; ASSOCIATION; POLYMORPHISMS; BIOLOGICS; THERAPY; DISEASE;

D O I：

10.1016/j.rdc.2017.04.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment of rheumatoid arthritis (RA) has substantially improved in recent years because of the development of novel drugs. However, response is not universal for any of the treatment options, and selection of an effective therapy is currently based on a trial-and-error approach. Delayed treatment response increases the risk of progressive joint damage and resultant disability and also has a significant impact on quality of life for patients. For many drugs, the patient's genetic background influences response to therapy, and understanding the genetics of response to therapy in RA may allow for targeted personalized health care.

引用

页码：377 / +

页数：12

共 58 条

[1]

Acosta-Colman I, 2013, PHARMACOGENOMICS, V14, P727, DOI [10.2217/PGS.13.60, 10.2217/pgs.13.60]

[2] Immunogenicity of Anti-TNF-α Agents in Autoimmune Diseases [J].

Aikawa, Nadia Emi ;

de Carvalho, Jozelio Freire ;

Almeida Silva, Clovis Artur ;

Bonfa, Eloisa .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2010, 38 (2-3) :82-89

[3] Development and Validation of Modified Disease Activity Scores in Rheumatoid Arthritis [J].

Baker, Joshua F. ;

Conaghan, Philip G. ;

Smolen, Josef S. ;

Aletaha, Daniel ;

Shults, Justine ;

Emery, Paul ;

Baker, Daniel G. ;

Ostergaard, Mikkel .

ARTHRITIS & RHEUMATOLOGY, 2014, 66 (04) :794-802

[4] Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort [J].

Bluett, James ;

Morgan, Catharine ;

Thurston, Layla ;

Plant, Darren ;

Hyrich, Kimme L. ;

Morgan, Ann W. ;

Wilson, Anthony G. ;

Isaacs, John D. ;

Cordingley, Lis ;

Barton, Anne .

RHEUMATOLOGY, 2015, 54 (03) :494-499

[5] Impact of Psychological Factors on Subjective Disease Activity Assessments in Patients With Severe Rheumatoid Arthritis [J].

Cordingley, Lis ;

Prajapati, Rita ;

Plant, Darren ;

Maskell, Deborah ;

Morgan, Catharine ;

Ali, Faisal R. ;

Morgan, Ann W. ;

Wilson, Anthony G. ;

Isaacs, John D. ;

Barton, Anne .

ARTHRITIS CARE & RESEARCH, 2014, 66 (06) :861-868

[6] THE ANTIINFLAMMATORY MECHANISM OF METHOTREXATE - INCREASED ADENOSINE RELEASE AT INFLAMED SITES DIMINISHES LEUKOCYTE ACCUMULATION IN AN IN-VIVO MODEL OF INFLAMMATION [J].

CRONSTEIN, BN ;

NAIME, D ;

OSTAD, E .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06) :2675-2682

[7] The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis [J].

Cui, Jing ;

Diogo, Dorothee ;

Stahl, Eli A. ;

Canhao, Helena ;

Mariette, Xavier ;

Greenberg, Jeffrey D. ;

Okada, Yukinori ;

Pappas, Dimitrios A. ;

Fulton, Robert S. ;

Tak, Paul P. ;

Nurmohamed, Michael T. ;

Lee, Annette ;

Larson, David E. ;

Kurreeman, Fina ;

Deluca, Tracie L. ;

O'Laughlin, Michelle ;

Fronick, Catrina C. ;

Fulton, Lucinda L. ;

Mardis, Elaine R. ;

van der Horst-Bruinsma, Irene E. ;

Wolbink, Gert-Jan ;

Gregersen, Peter K. ;

Kremer, Joel M. ;

Crusius, J. Bart A. ;

de Vries, Niek ;

Huizinga, Tom W. J. ;

Fonseca, Joao Eurico ;

Miceli-Richard, Corinne ;

Karlson, Elizabeth W. ;

Coenen, Marieke J. H. ;

Barton, Anne ;

Plenge, Robert M. ;

Raychaudhuri, Soumya .

ARTHRITIS & RHEUMATOLOGY, 2017, 69 (04) :735-741

[8] Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis [J].

Cui, Jing ;

Stahl, Eli A. ;

Saevarsdottir, Saedis ;

Miceli, Corinne ;

Diogo, Dorothee ;

Trynka, Gosia ;

Raj, Towfique ;

Mirkov, Masa Umicevic ;

Canhao, Helena ;

Ikari, Katsunori ;

Terao, Chikashi ;

Okada, Yukinori ;

Wedren, Sara ;

Askling, Johan ;

Yamanaka, Hisashi ;

Momohara, Shigeki ;

Taniguchi, Atsuo ;

Ohmura, Koichiro ;

Matsuda, Fumihiko ;

Mimori, Tsuneyo ;

Gupta, Namrata ;

Kuchroo, Manik ;

Morgan, Ann W. ;

Isaacs, John D. ;

Wilson, Anthony G. ;

Hyrich, Kimme L. ;

Herenius, Marieke ;

Doorenspleet, Marieke E. ;

Tak, Paul-Peter ;

Crusius, J. Bart A. ;

van der Horst-Bruinsma, Irene E. ;

Wolbink, Gert Jan ;

van Riel, Piet L. C. M. ;

van de Laar, Mart ;

Guchelaar, Henk-Jan ;

Shadick, Nancy A. ;

Allaart, Cornelia F. ;

Huizinga, Tom W. J. ;

Toes, Rene E. M. ;

Kimberly, Robert P. ;

Bridges, S. Louis, Jr. ;

Criswell, Lindsey A. ;

Moreland, Larry W. ;

Fonseca, Joao Eurico ;

de Vries, Niek ;

Stranger, Barbara E. ;

De Jager, Philip L. ;

Raychaudhuri, Soumya ;

Weinblatt, Michael E. ;

Gregersen, Peter K. .

PLOS GENETICS, 2013, 9 (03)

[9] Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti-Tumor Necrosis Factor α Therapy [J].

Cui, Jing ;

Saevarsdottir, Saedis ;

Thomson, Brian ;

Padyukov, Leonid ;

van der Helm-van Mil, Annette H. M. ;

Nititham, Joanne ;

Hughes, Laura B. ;

de Vries, Niek ;

Raychaudhuri, Soumya ;

Alfredsson, Lars ;

Askling, Johan ;

Wedren, Sara ;

Ding, Bo ;

Guiducci, Candace ;

Wolbink, Gert Jan ;

Crusius, J. Bart A. ;

van der Horst-Bruinsma, Irene E. ;

Herenius, Marieke ;

Weinblatt, Michael E. ;

Shadick, Nancy A. ;

Worthington, Jane ;

Batliwalla, Franak ;

Kern, Marlena ;

Morgan, Ann W. ;

Wilson, Anthony G. ;

Isaacs, John D. ;

Hyrich, Kimme ;

Seldin, Michael F. ;

Moreland, Larry W. ;

Behrens, Timothy W. ;

Allaart, Cornelia F. ;

Criswell, Lindsey A. ;

Huizinga, Tom W. J. ;

Tak, Paul P. ;

Bridges, S. Louis, Jr. ;

Toes, Rene E. M. ;

Barton, Anne ;

Klareskog, Lars ;

Gregersen, Peter K. ;

Karlson, Elizabeth W. ;

Plenge, Robert M. .

ARTHRITIS AND RHEUMATISM, 2010, 62 (07) :1849-1861

[10] Contribution of common polymorphisms in reduced folate carrier and γ-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis [J].

Dervieux, T ;

Kremer, J ;

Lein, DO ;

Capps, R ;

Barham, R ;

Meyer, G ;

Smith, K ;

Caldwell, J ;

Furst, DE .

PHARMACOGENETICS, 2004, 14 (11) :733-739

← 1 2 3 4 5 6 →