DNA replication: a complex matter

被引：46
作者：
Frouin, I
Montecucco, A
Spadari, S
Maga, G
机构：
[1] CNR, Ist Genet Mol, I-27100 Pavia, Italy
[2] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8050 Zurich, Switzerland
来源：
EMBO REPORTS | 2003年 / 4卷 / 07期
关键词：
D O I：
10.1038/sj.embor.embor886
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In eukaryotic cells, the essential function of DNA replication is carried out by a network of enzymes and proteins, which work together to rapidly and accurately duplicate the genetic information of the cell. Many of the components of this DNA replication apparatus associate with other cellular factors as components of multiprotein complexes, which act cooperatively in networks to regulate cell cycle progression and checkpoint control, but are distinct from the prereplication complexes that associate with the origins and regulate their firing. In this review, we summarize current knowledge about the composition and dynamics of these large multiprotein complexes in mammalian cells and their relationships to the replication factories.
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收藏
页码：666 / 670
页数：5
相关论文
共 52 条
[21]   A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation [J].
Koundrioukoff, S ;
Jónsson, ZO ;
Hasan, S ;
de Jong, RN ;
van der Vliet, PC ;
Hottiger, MO ;
Hübscher, U .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :22882-22887
[22]   CHROMATIN-ASSEMBLY-FACTOR-1 (CAF-1) COLOCALIZES WITH REPLICATION FOCI IN HELA-CELL NUCLEI [J].
KRUDE, T .
EXPERIMENTAL CELL RESEARCH, 1995, 220 (02) :304-311
[23]   Dynamics of DNA replication factories in living cells [J].
Leonhardt, H ;
Rahn, HP ;
Weinzierl, P ;
Sporbert, A ;
Cremer, T ;
Zink, D ;
Cardoso, MC .
JOURNAL OF CELL BIOLOGY, 2000, 149 (02) :271-279
[24]   A TARGETING SEQUENCE DIRECTS DNA METHYLTRANSFERASE TO SITES OF DNA-REPLICATION IN MAMMALIAN NUCLEI [J].
LEONHARDT, H ;
PAGE, AW ;
WEIER, HU ;
BESTOR, TH .
CELL, 1992, 71 (05) :865-873
[25]   Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair [J].
Levin, DS ;
McKenna, AE ;
Motycka, TA ;
Matsumoto, Y ;
Tomkinson, AE .
CURRENT BIOLOGY, 2000, 10 (15) :919-922
[26]   Spatial and temporal dynamics of DNA replication sites in mammalian cells [J].
Ma, H ;
Samarabandu, J ;
Devdhar, RS ;
Acharya, R ;
Cheng, PC ;
Meng, CL ;
Berezney, R .
JOURNAL OF CELL BIOLOGY, 1998, 143 (06) :1415-1425
[27]   DNA polymerase switching:: I.: Replication factor C displaces DNA polymerase α prior to PCNA loading [J].
Maga, G ;
Stucki, M ;
Spadari, S ;
Hübscher, U .
JOURNAL OF MOLECULAR BIOLOGY, 2000, 295 (04) :791-801
[28]   DNA replication machinery: Functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer [J].
Maga, G ;
Hubscher, U .
BIOCHEMISTRY, 1996, 35 (18) :5764-5777
[29]   Okazaki fragment processing:: Modulation of the strand displacement activity of DNA polymerase δ by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1 [J].
Maga, G ;
Villani, G ;
Tillement, V ;
Stucki, M ;
Locatelli, GA ;
Frouin, I ;
Spadari, S ;
Hübscher, U .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14298-14303
[30]  
Malkas LH, 1998, J CELL BIOCHEM, P18
123456