DNA replication: a complex matter

被引：46
作者：
Frouin, I
Montecucco, A
Spadari, S
Maga, G
机构：
[1] CNR, Ist Genet Mol, I-27100 Pavia, Italy
[2] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8050 Zurich, Switzerland
来源：
EMBO REPORTS | 2003年 / 4卷 / 07期
关键词：
D O I：
10.1038/sj.embor.embor886
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In eukaryotic cells, the essential function of DNA replication is carried out by a network of enzymes and proteins, which work together to rapidly and accurately duplicate the genetic information of the cell. Many of the components of this DNA replication apparatus associate with other cellular factors as components of multiprotein complexes, which act cooperatively in networks to regulate cell cycle progression and checkpoint control, but are distinct from the prereplication complexes that associate with the origins and regulate their firing. In this review, we summarize current knowledge about the composition and dynamics of these large multiprotein complexes in mammalian cells and their relationships to the replication factories.
引用
收藏
页码：666 / 670
页数：5
相关论文
共 52 条
[1]   Okazaki fragment maturation in yeast - I. Distribution of functions between FEN1 AND DNA2 [J].
Ayyagari, R ;
Gomes, XV ;
Gordenin, DA ;
Burgers, PMJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1618-1625
[2]   RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes [J].
Bae, SH ;
Bae, KH ;
Kim, JA ;
Seo, YS .
NATURE, 2001, 412 (6845) :456-461
[3]   hMYH cell cycle-dependent expression, subcellular localization and association with replication foci:: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs [J].
Boldogh, I ;
Milligan, D ;
Lee, MS ;
Bassett, H ;
Lloyd, RS ;
McCullough, AK .
NUCLEIC ACIDS RESEARCH, 2001, 29 (13) :2802-2809
[4]   REVERSAL OF TERMINAL DIFFERENTIATION AND CONTROL OF DNA-REPLICATION - CYCLIN-A AND CDK2 SPECIFICALLY LOCALIZE AT SUBNUCLEAR SITES OF DNA-REPLICATION [J].
CARDOSO, MC ;
LEONHARDT, H ;
NADALGINARD, B .
CELL, 1993, 74 (06) :979-992
[5]   Human DNA (cytosine-5) methyltransferase PCNA complex as a target for p21(WAF1) [J].
Chuang, LSH ;
Ian, HI ;
Koh, TW ;
Ng, HH ;
Xu, GL ;
Li, BFL .
SCIENCE, 1997, 277 (5334) :1996-2000
[6]   Molecular biology - The organization of replication and transcription [J].
Cook, PR .
SCIENCE, 1999, 284 (5421) :1790-1795
[7]   Two immunologically distinct human DNA polymerase α-primase subpopulations are involved in cellular DNA replication [J].
Dehde, S ;
Rohaly, G ;
Schub, O ;
Nasheuer, HP ;
Bohn, W ;
Chemnitz, J ;
Deppert, W ;
Dornreiter, I .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (07) :2581-2593
[8]   Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis [J].
Dimitrova, DS ;
Gilbert, DM .
NATURE CELL BIOLOGY, 2000, 2 (10) :686-694
[9]   A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells [J].
Fotedar, R ;
Mossi, R ;
Fitzgerald, P ;
Rousselle, T ;
Maga, G ;
Brickner, H ;
Messier, H ;
Kasibhatla, S ;
Hubscher, U ;
Fotedar, A .
EMBO JOURNAL, 1996, 15 (16) :4423-4433
[10]   Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins [J].
Frouin, I ;
Montecucco, A ;
Biamonti, G ;
Hübscher, U ;
Spadari, S ;
Maga, G .
EMBO JOURNAL, 2002, 21 (10) :2485-2495
123456