Initial experience with ocriplasmin in the treatment of vitreomacular traction

被引：1

作者：

Botto de Barros Garcia, Jose Mauricio ^{[1
,2
]}

Cruvinel Isaac, David Leonardo ^{[1
,2
]}

Avila, Marcos ^{[1
,2
]}

机构：

[1] Ctr Referencia Oftalmol CEROF, Dept Ophthalmol, Goiania, Go, Brazil

[2] Univ Fed Goias, Dept Ophthalmol, Goiania, Go, Brazil

来源：

ARQUIVOS BRASILEIROS DE OFTALMOLOGIA | 2016年 / 79卷 / 02期

关键词：

Vitreous body/pathology; Fibrinolytic agents/therapeutic use; Fibrinolysin/therapeutic use; Tomography; optical coherence; Tertiary care centers; INTRAVITREAL OCRIPLASMIN; ADHESION; OUTCOMES;

D O I：

10.5935/0004-2749.20160026

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

This study aimed to report the clinical and structural outcomes of intravitreal ocriplasmin in the treatment of vitreomacular interface disorders in two tertiary centers in Brazil. A retrospective study was performed by reviewing medical records and spectral domain optical coherence tomography (SD-OCT) findings of seven patients who were treated with a single ocriplasmin injection. A total of 57.14% of patients achieved resolution of vitreomacular traction as evidenced by SD-OCT. Regarding our functional results, 87.71% maintained or improved visual acuity after follow-up. To the best of our knowledge, this is the first study reporting initial results of ocriplasmin therapy in Brazil.

引用

页码：85 / 87

页数：3

共 10 条

[1] Pharmacokinetics of Ocriplasmin in Vitreous
de Smet, Marc D.
Jonckx, Bart
Vanhove, Marc
van Calster, Joachim
Stalmans, Peter
Stassen, Jean Marie
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (13) : 8208 - 8213
[2] The International Vitreomacular Traction Study Group Classification of Vitreomacular Adhesion, Traction, and Macular Hole
Duker, Jay S.
Kaiser, Peter K.
Binder, Susanne
de Smet, Marc D.
Gaudric, Alain
Reichel, Elias
Sadda, SriniVas R.
Sebag, Jerry
Spaide, Richard F.
Stalmans, Peter
[J]. OPHTHALMOLOGY, 2013, 120 (12) : 2611 - 2619
[3] NOVEL METHOD FOR ANALYZING SNELLEN VISUAL ACUITY MEASUREMENTS
Gregori, Ninel Z.
Feuer, William
Rosenfeld, Philip J.
[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2010, 30 (07): : 1046 - 1050
[4] Initial Outcomes Following Intravitreal Ocriplasmin for Treatment of Symptomatic Vitreomacular Adhesion
Kim, Brian T.
Schwartz, Stephen G.
Smiddy, William E.
Doshi, Rishi R.
Kovach, Jaclyn L.
Berrocal, Audina M.
Moshfeghi, Andrew A.
Fortun, Jorge A.
[J]. OPHTHALMIC SURGERY LASERS & IMAGING, 2013, 44 (04) : 334 - 343
[5] A retrospective study of a single practice use of ocriplasmin in the treatment of vitreomacular traction
Knudsen, Victoria Morrison
Kozak, Igor
[J]. SAUDI JOURNAL OF OPHTHALMOLOGY, 2014, 28 (02) : 139 - 144
[6] Kuppermann Baruch D, 2012, Retina, V32 Suppl 2, pS225, DOI 10.1097/IAE.0b013e31825bc593
[7] Anatomical and visual outcomes following ocriplasmin treatment for symptomatic vitreomacular traction syndrome
Singh, Rishi P.
Li, Ang
Bedi, Rumneek
Srivastava, Sunil
Sears, Jonathan E.
Ehlers, Justis P.
Schachat, Andrew P.
Kaiser, Peter K.
[J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2014, 98 (03) : 356 - 360
[8] Enzymatic Vitreolysis with Ocriplasmin for Vitreomacular Traction and Macular Holes
Stalmans, Peter
Benz, Matthew S.
Gandorfer, Arnd
Kampik, Anselm
Girach, Aniz
Pakola, Stephen
Haller, Julia A.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (07) : 606 - 615
[9] Treatment Outcomes and Spectral-Domain Optical Coherence Tomography Findings of Eyes With Symptomatic Vitreomacular Adhesion Treated With Intravitreal Ocriplasmin
Warrow, David J.
Lai, Michael M.
Patel, Auvni
Raevis, Joseph
Berinstein, Daniel M.
[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2015, 159 (01) : 20 - 30
[10] Frequency of Vitreomacular Interface Disease in Patients Presenting to a Tertiary Care Institution
Xu, Lucy T.
Punjabi, Omar S.
Shao, Jack
Ehlers, Justis P.
Srivastava, Sunil K.
Singh, Rishi P.
Kaiser, Peter K.
[J]. OPHTHALMIC SURGERY LASERS & IMAGING RETINA, 2014, 45 (06) : 517 - 520

← 1 →