Developing natural marine products for treating liver diseases

被引:4
作者
Wei, Qian [1 ]
Guo, Jin-Sheng [1 ]
机构
[1] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol & Hepatol, 180 Feng Lin Rd, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
Natural marine products; Liver disease; Treatment; Liver; HEPATITIS-C VIRUS; HEPATOCELLULAR-CARCINOMA; MOLECULAR-WEIGHT; APOPTOSIS; FUCOIDAN; MICE; PATHOGENESIS; SUPPRESSION; INJURY;
D O I
10.12998/wjcc.v10.i8.2369
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In recent years, marine-derived bioactive compounds have gained increasing attention because of their higher biodiversity vs land-derived compounds. A number of marine-derived compounds are proven to improve lipid metabolism, modulate the gut microbiota, and possess anti-inflammatory, antioxidant, antibacterial, antiviral, and antitumor activities. With the increasing understanding of the molecular landscape underlying the pathogenesis of chronic liver diseases, interest has spiked in developing new therapeutic drugs and medicine food homology from marine sources for the prevention and treatment of liver diseases.
引用
收藏
页码:2369 / 2381
页数:13
相关论文
共 61 条
[21]   Anticancer Effect of Nemopilema nomurai Jellyfish Venom on HepG2 Cells and a Tumor Xenograft Animal Model [J].
Lee, Hyunkyoung ;
Bae, Seong Kyeong ;
Kim, Munki ;
Pyo, Min Jung ;
Kim, Minkyung ;
Yang, Sujeoung ;
Won, Chung-kil ;
Yoon, Won Duk ;
Han, Chang Hoon ;
Kang, Changkeun ;
Kim, Euikyung .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 2017
[22]   Harzianoic acids A and B, new natural scaffolds with inhibitory effects against hepatitis C virus [J].
Li, Bo ;
Li, Li ;
Peng, Zonggen ;
Liu, Dong ;
Si, Longlong ;
Wang, Jing ;
Yuan, Bochuan ;
Huang, Jian ;
Proksch, Peter ;
Lin, Wenhan .
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (03) :560-567
[23]   Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent [J].
Li, Jingjing ;
Guo, Chuanyong ;
Wu, Jianye .
DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 :2275-2285
[24]   Regulatory Efficacy of the Polyunsaturated Fatty Acids from Microalgae Spirulina platensis on Lipid Metabolism and Gut Microbiota in High-Fat Diet Rats [J].
Li, Tian-Tian ;
Liu, Yuan-Yuan ;
Wan, Xu-Zhi ;
Huang, Zi-Rui ;
Liu, Bin ;
Zhao, Chao .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (10)
[25]   Phycobiliproteins: Molecular structure, production, applications, and prospects [J].
Li, Wenjun ;
Su, Hai-Nan ;
Pu, Yang ;
Chen, Jun ;
Liu, Lu-Ning ;
Liu, Qi ;
Qin, Song .
BIOTECHNOLOGY ADVANCES, 2019, 37 (02) :340-353
[26]   Marine collagen peptides protect against early alcoholic liver injury in rats [J].
Lin, Bing ;
Zhang, Feng ;
Yu, Yongchao ;
Jiang, Qinghao ;
Zhang, Zhaofeng ;
Wang, Junbo ;
Li, Yong .
BRITISH JOURNAL OF NUTRITION, 2012, 107 (08) :1160-1166
[27]   Lobohedleolide suppresses hepatitis C virus replication via JNK/c-Jun-C/EBP-mediated downregulation of cyclooxygenase-2 expression [J].
Lin, Chun-Kuang ;
Tseng, Chin-Kai ;
Liaw, Chih-Chuang ;
Huang, Chiung-Yao ;
Wei, Chih-Ku ;
Sheu, Jyh-Horng ;
Lee, Jin-Ching .
SCIENTIFIC REPORTS, 2018, 8
[28]   Comparative Transcriptome Analyses Provide Potential Insights into the Molecular Mechanisms of Astaxanthin in the Protection against Alcoholic Liver Disease in Mice [J].
Liu, Huilin ;
Liu, Huimin ;
Zhu, Lingyu ;
Zhang, Ziqi ;
Zheng, Xin ;
Liu, Jingsheng ;
Fu, Xueqi .
MARINE DRUGS, 2019, 17 (03)
[29]   Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis [J].
Milito, Alfonsina ;
Brancaccio, Mariarita ;
D'Argenio, Giuseppe ;
Castellano, Immacolata .
CELLS, 2019, 8 (11)
[30]   Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection [J].
Mori, Naoki ;
Nakasone, Kazunori ;
Tomimori, Koh ;
Ishikawa, Chie .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (18) :2225-2230