Antifungal susceptibility patterns of a global collection of fungal isolates: results of the SENTRY Antifungal Surveillance Program (2013)

被引：124

作者：

Castanheira, Mariana ^{[1
]}

Messer, Shawn A. ^{[1
]}

Rhomberg, Paul R. ^{[1
]}

Pfaller, Michael A. ^{[1
,2
]}

机构：

[1] JMI Labs, North Liberty, IA USA

[2] T2Biosystems, Lexington, MA USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 85卷 / 02期

关键词：

Candida; Aspergillus; Antifungal susceptibility; Surveillance; EPIDEMIOLOGIC CUTOFF VALUES; ISAVUCONAZOLE MIC DISTRIBUTIONS; INFECTIOUS-DISEASES SOCIETY; CLINICAL-PRACTICE GUIDELINE; BROTH MICRODILUTION METHOD; FKS MUTATIONS; ECHINOCANDIN RESISTANCE; ASPERGILLUS-FUMIGATUS; AZOLE RESISTANCE; DRUG-RESISTANCE;

D O I：

10.1016/j.diagmicrobio.2016.02.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Among 1846 fungal clinical isolates from 31 countries, echinocandin resistance in Candida spp. ranged from 0.0% to 2.8% (highest for anidulafungin versus Candida glabrata), and fluconazole resistance was noted among 11.9% and 11.6% of the C. glabrata and Candida tropicalis, respectively. Two isolates of Aspergillus fumigatus displayed elevated MICs for itraconazole and carried cyp51a mutations encoding TR34 L98H. All Cryptococcus neoformans had azole MIC values below epidemiological cutoff values. The increasing resistance among certain species and more frequent reports of breakthrough infections in patients undergoing antifungal therapy highlights the importance of antifungal surveillance to guide therapy for patients with invasive fungal infections. (C) 2016 Elsevier Inc. All rights reserved.

引用

收藏

页码：200 / 204

页数：5

相关论文

共 21 条

[1] Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations [J].

Alexander, Barbara D. ;

Johnson, Melissa D. ;

Pfeiffer, Christopher D. ;

Jimenez-Ortigosa, Cristina ;

Catania, Jelena ;

Booker, Rachel ;

Castanheira, Mariana ;

Messer, Shawn A. ;

Perlin, David S. ;

Pfaller, Michael A. .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (12) :1724-1732

[2]

[Anonymous], 2008, Reference method for broth dilution antifungal susceptibility testing of yeasts

[3] Update on antifungal resistance in Aspergillus and Candida [J].

Arendrup, M. C. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 :42-48

[4] Frequency of fks Mutations among Candida glabrata Isolates from a 10-Year Global Collection of Bloodstream Infection Isolates [J].

Castanheira, Mariana ;

Woosley, Leah N. ;

Messer, Shawn A. ;

Diekema, Daniel J. ;

Jones, Ronald N. ;

Pfaller, Michael A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (01) :577-580

[5] Candida guilliermondii and Other Species of Candida Misidentified as Candida famata: Assessment by Vitek 2, DNA Sequencing Analysis, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry in Two Global Antifungal Surveillance Programs [J].

Castanheira, Mariana ;

Woosley, Leah N. ;

Diekema, Daniel J. ;

Jones, Ronald N. ;

Pfaller, Michael A. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (01) :117-124

[6] Low Prevalence of fks1 Hot Spot 1 Mutations in a Worldwide Collection of Candida Strains [J].

Castanheira, Mariana ;

Woosley, Leah N. ;

Diekema, Daniel J. ;

Messer, Shawn A. ;

Jones, Ronald N. ;

Pfaller, Michael A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (06) :2655-2659

[7] Changes in Incidence and Antifungal Drug Resistance in Candidemia: Results From Population-Based Laboratory Surveillance in Atlanta and Baltimore, 2008-2011 [J].

Cleveland, Angela Ahlquist ;

Farley, Monica M. ;

Harrison, Lee H. ;

Stein, Betsy ;

Hollick, Rosemary ;

Lockhart, Shawn R. ;

Magill, Shelley S. ;

Derado, Gordana ;

Park, Benjamin J. ;

Chiller, Tom M. .

CLINICAL INFECTIOUS DISEASES, 2012, 55 (10) :1352-1361

[8]

CLSI, 2008, REF METH BROTH DIL A, V28

[9] Multicenter Study of Isavuconazole MIC Distributions and Epidemiological Cutoff Values for the Cryptococcus neoformans-Cryptococcus gattii Species Complex Using the CLSI M27-A3 Broth Microdilution Method [J].

Espinel-Ingroff, A. ;

Chowdhary, A. ;

Gonzalez, G. M. ;

Guinea, J. ;

Hagen, F. ;

Meis, J. F. ;

Thompson, G. R., III ;

Turnidge, J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (01) :666-668

[10] Multilaboratory Study of Epidemiological Cutoff Values for Detection of Resistance in Eight Candida Species to Fluconazole, Posaconazole, and Voriconazole [J].

Espinel-Ingroff, A. ;

Pfaller, M. A. ;

Bustamante, B. ;

Canton, E. ;

Fothergill, A. ;

Fuller, J. ;

Gonzalez, G. M. ;

Lass-Floerl, C. ;

Lockhart, S. R. ;

Martin-Mazuelos, E. ;

Meis, J. F. ;

Melhem, M. S. C. ;

Ostrosky-Zeichner, L. ;

Pelaez, T. ;

Szeszs, M. W. ;

St-Germain, G. ;

Bonefietti, L. X. ;

Guarro, J. ;

Turnidge, J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (04) :2006-2012